Cardiac aging - Getting to the stem of the problem

Nirmala Hariharan, Mark A. Sussman

Research output: Contribution to journalReview articlepeer-review

36 Scopus citations


Cardiac aging is a heterogeneous process caused by a combination of stochastic events which manifests as loss of structure and function in the heart, however several recent studies draw attention to aging being primarily a stem cell problem. This review summarizes findings in support of the "stem cell hypothesis of aging" and discusses the impact of age on cardiac stem cells and the niche. This article is part of a Special Issue entitled 'CV Aging'.

Original languageEnglish (US)
Pages (from-to)32-36
Number of pages5
JournalJournal of Molecular and Cellular Cardiology
StatePublished - Jun 1 2015
Externally publishedYes


  • Aging
  • Cardiac stem/progenitor cells
  • Heart

ASJC Scopus subject areas

  • Molecular Biology
  • Cardiology and Cardiovascular Medicine


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