Abstract
Cardiac aging is a heterogeneous process caused by a combination of stochastic events which manifests as loss of structure and function in the heart, however several recent studies draw attention to aging being primarily a stem cell problem. This review summarizes findings in support of the "stem cell hypothesis of aging" and discusses the impact of age on cardiac stem cells and the niche. This article is part of a Special Issue entitled 'CV Aging'.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 32-36 |
| Number of pages | 5 |
| Journal | Journal of Molecular and Cellular Cardiology |
| Volume | 83 |
| DOIs | |
| State | Published - Jun 1 2015 |
| Externally published | Yes |
Fingerprint
Keywords
- Aging
- Cardiac stem/progenitor cells
- Heart
ASJC Scopus subject areas
- Molecular Biology
- Cardiology and Cardiovascular Medicine
Cite this
Cardiac aging - Getting to the stem of the problem. / Hariharan, Nirmala; Sussman, Mark A.
In: Journal of Molecular and Cellular Cardiology, Vol. 83, 01.06.2015, p. 32-36.Research output: Contribution to journal › Review article
}
TY - JOUR
T1 - Cardiac aging - Getting to the stem of the problem
AU - Hariharan, Nirmala
AU - Sussman, Mark A.
PY - 2015/6/1
Y1 - 2015/6/1
N2 - Cardiac aging is a heterogeneous process caused by a combination of stochastic events which manifests as loss of structure and function in the heart, however several recent studies draw attention to aging being primarily a stem cell problem. This review summarizes findings in support of the "stem cell hypothesis of aging" and discusses the impact of age on cardiac stem cells and the niche. This article is part of a Special Issue entitled 'CV Aging'.
AB - Cardiac aging is a heterogeneous process caused by a combination of stochastic events which manifests as loss of structure and function in the heart, however several recent studies draw attention to aging being primarily a stem cell problem. This review summarizes findings in support of the "stem cell hypothesis of aging" and discusses the impact of age on cardiac stem cells and the niche. This article is part of a Special Issue entitled 'CV Aging'.
KW - Aging
KW - Cardiac stem/progenitor cells
KW - Heart
UR - http://www.scopus.com/inward/record.url?scp=84937978904&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84937978904&partnerID=8YFLogxK
U2 - 10.1016/j.yjmcc.2015.04.008
DO - 10.1016/j.yjmcc.2015.04.008
M3 - Review article
C2 - 25886698
AN - SCOPUS:84937978904
VL - 83
SP - 32
EP - 36
JO - Journal of Molecular and Cellular Cardiology
JF - Journal of Molecular and Cellular Cardiology
SN - 0022-2828
ER -