Cardiac aging - Getting to the stem of the problem

Nirmala Hariharan; Mark A. Sussman

doi:10.1016/j.yjmcc.2015.04.008

Cardiac aging - Getting to the stem of the problem

Nirmala Hariharan, Mark A. Sussman

Research output: Contribution to journal › Review article › peer-review

36 Scopus citations

Abstract

Cardiac aging is a heterogeneous process caused by a combination of stochastic events which manifests as loss of structure and function in the heart, however several recent studies draw attention to aging being primarily a stem cell problem. This review summarizes findings in support of the "stem cell hypothesis of aging" and discusses the impact of age on cardiac stem cells and the niche. This article is part of a Special Issue entitled 'CV Aging'.

Original language	English (US)
Pages (from-to)	32-36
Number of pages	5
Journal	Journal of Molecular and Cellular Cardiology
Volume	83
DOIs	https://doi.org/10.1016/j.yjmcc.2015.04.008
State	Published - Jun 1 2015
Externally published	Yes

Keywords

Aging
Cardiac stem/progenitor cells
Heart

ASJC Scopus subject areas

Molecular Biology
Cardiology and Cardiovascular Medicine

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10.1016/j.yjmcc.2015.04.008

Cite this

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abstract = "Cardiac aging is a heterogeneous process caused by a combination of stochastic events which manifests as loss of structure and function in the heart, however several recent studies draw attention to aging being primarily a stem cell problem. This review summarizes findings in support of the {"}stem cell hypothesis of aging{"} and discusses the impact of age on cardiac stem cells and the niche. This article is part of a Special Issue entitled 'CV Aging'.",

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AU - Sussman, Mark A.

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AB - Cardiac aging is a heterogeneous process caused by a combination of stochastic events which manifests as loss of structure and function in the heart, however several recent studies draw attention to aging being primarily a stem cell problem. This review summarizes findings in support of the "stem cell hypothesis of aging" and discusses the impact of age on cardiac stem cells and the niche. This article is part of a Special Issue entitled 'CV Aging'.

KW - Aging

KW - Cardiac stem/progenitor cells

KW - Heart

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C2 - 25886698

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ER -

Cardiac aging - Getting to the stem of the problem

Abstract

Keywords

ASJC Scopus subject areas

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