Cardiac activation mapping by MRI

Friedrich D Knollmann, Jürgen Mäurer, Helmut Kücherer, Johannes C. Böck, J. William O'Connell, Elias Botvinick, Hermann W. Eichstädt, Roland Felix

Research output: Contribution to journalArticlepeer-review

3 Scopus citations


To establish cardiac MRI as a tool for noninvasive evaluation of activation patterns, 10 healthy volunteers were examined by cine segmented turboFLASH imaging sequences. Sequence modifications for low signal blood- pool appearance were applied, i.e., bilateral spatial saturation for segmented turboFLASH imaging. Pixelwise calculation of first-harmonic Fourier phase values (displayed as color-encoded maps) reveal either anterior septal or left ventricular free-wall sites as areas of earliest phase spreading towards posterior paraseptal sites in segmented turboFLASH scans. Phase scatter is lower in unsaturated than spatially presaturated segmented turboFLASH studies. Phase standard deviation in areas of endocardial displacement is higher in basal than apical slice positions in these scans. Early results indicate that first-harmonic Fourier phase analysis of cardiac- segmented turboFLASH MRI cine studies may provide a tool for noninvasive studies of cardiac activation sequence.

Original languageEnglish (US)
Pages (from-to)19-25
Number of pages7
JournalMagnetic Resonance Materials in Physics, Biology, and Medicine
Issue number1
StatePublished - 1996
Externally publishedYes


  • cardiac activation sequence
  • Fourier phase analysis
  • magnetic resonance imaging

ASJC Scopus subject areas

  • Biophysics
  • Genetics


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