Carbohydrates in transplantation

Xi Chen; Peter R. Andreana; Peng George Wang

doi:10.1016/S1367-5931(99)00022-8

Carbohydrates in transplantation

Xi Chen, Peter R. Andreana, Peng George Wang

Research output: Contribution to journal › Article

33 Scopus citations

Abstract

Carbohydrate materials have become increasingly utilized in transplantation and cell/tissue engineering within the past year. This has been well documented in recent applications of immobilized or soluble α-galactosyl epitopes (i.e. oligosaccharides with a terminal Galα1-3Gal sequence) in preventing hyperacute rejection in pig-to-primate xenotransplantation. In addition, α-galactosyl polymers have been shown to exhibit much greater activity (up to 10⁴ times) than α-galactosyl monomers in inhibiting the binding of anti-galactosyl antibodies to pig kidney epithelial cells and assisting in the prevention of cytotoxicity in human serum.

Original language	English (US)
Pages (from-to)	650-658
Number of pages	9
Journal	Current Opinion in Chemical Biology
Volume	3
Issue number	6
DOIs	https://doi.org/10.1016/S1367-5931(99)00022-8
State	Published - Dec 1 1999
Externally published	Yes

ASJC Scopus subject areas

Biochemistry

Access to Document

10.1016/S1367-5931(99)00022-8

Fingerprint Dive into the research topics of 'Carbohydrates in transplantation'. Together they form a unique fingerprint.

Cite this

Chen, X., Andreana, P. R., & Wang, P. G. (1999). Carbohydrates in transplantation. Current Opinion in Chemical Biology, 3(6), 650-658. https://doi.org/10.1016/S1367-5931(99)00022-8

@article{fdeb9b5c103744a5abd85ab2e166515a,

title = "Carbohydrates in transplantation",

abstract = "Carbohydrate materials have become increasingly utilized in transplantation and cell/tissue engineering within the past year. This has been well documented in recent applications of immobilized or soluble α-galactosyl epitopes (i.e. oligosaccharides with a terminal Galα1-3Gal sequence) in preventing hyperacute rejection in pig-to-primate xenotransplantation. In addition, α-galactosyl polymers have been shown to exhibit much greater activity (up to 104 times) than α-galactosyl monomers in inhibiting the binding of anti-galactosyl antibodies to pig kidney epithelial cells and assisting in the prevention of cytotoxicity in human serum.",

author = "Xi Chen and Andreana, {Peter R.} and Wang, {Peng George}",

year = "1999",

month = dec,

day = "1",

doi = "10.1016/S1367-5931(99)00022-8",

language = "English (US)",

volume = "3",

pages = "650--658",

journal = "Current Opinion in Chemical Biology",

issn = "1367-5931",

publisher = "Elsevier Limited",

number = "6",

}

TY - JOUR

T1 - Carbohydrates in transplantation

AU - Chen, Xi

AU - Andreana, Peter R.

AU - Wang, Peng George

PY - 1999/12/1

Y1 - 1999/12/1

N2 - Carbohydrate materials have become increasingly utilized in transplantation and cell/tissue engineering within the past year. This has been well documented in recent applications of immobilized or soluble α-galactosyl epitopes (i.e. oligosaccharides with a terminal Galα1-3Gal sequence) in preventing hyperacute rejection in pig-to-primate xenotransplantation. In addition, α-galactosyl polymers have been shown to exhibit much greater activity (up to 104 times) than α-galactosyl monomers in inhibiting the binding of anti-galactosyl antibodies to pig kidney epithelial cells and assisting in the prevention of cytotoxicity in human serum.

AB - Carbohydrate materials have become increasingly utilized in transplantation and cell/tissue engineering within the past year. This has been well documented in recent applications of immobilized or soluble α-galactosyl epitopes (i.e. oligosaccharides with a terminal Galα1-3Gal sequence) in preventing hyperacute rejection in pig-to-primate xenotransplantation. In addition, α-galactosyl polymers have been shown to exhibit much greater activity (up to 104 times) than α-galactosyl monomers in inhibiting the binding of anti-galactosyl antibodies to pig kidney epithelial cells and assisting in the prevention of cytotoxicity in human serum.

UR - http://www.scopus.com/inward/record.url?scp=0032707333&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0032707333&partnerID=8YFLogxK

U2 - 10.1016/S1367-5931(99)00022-8

DO - 10.1016/S1367-5931(99)00022-8

M3 - Article

C2 - 10600719

AN - SCOPUS:0032707333

VL - 3

SP - 650

EP - 658

JO - Current Opinion in Chemical Biology

JF - Current Opinion in Chemical Biology

SN - 1367-5931

IS - 6

ER -