Carbohydrates in transplantation

Xi Chen; Peter R. Andreana; Peng George Wang

doi:10.1016/S1367-5931(99)00022-8

Carbohydrates in transplantation

Xi Chen, Peter R. Andreana, Peng George Wang

Research output: Contribution to journal › Article › peer-review

33 Scopus citations

Abstract

Carbohydrate materials have become increasingly utilized in transplantation and cell/tissue engineering within the past year. This has been well documented in recent applications of immobilized or soluble α-galactosyl epitopes (i.e. oligosaccharides with a terminal Galα1-3Gal sequence) in preventing hyperacute rejection in pig-to-primate xenotransplantation. In addition, α-galactosyl polymers have been shown to exhibit much greater activity (up to 10⁴ times) than α-galactosyl monomers in inhibiting the binding of anti-galactosyl antibodies to pig kidney epithelial cells and assisting in the prevention of cytotoxicity in human serum.

Original language	English (US)
Pages (from-to)	650-658
Number of pages	9
Journal	Current Opinion in Chemical Biology
Volume	3
Issue number	6
DOIs	https://doi.org/10.1016/S1367-5931(99)00022-8
State	Published - Dec 1 1999
Externally published	Yes

ASJC Scopus subject areas

Biochemistry

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abstract = "Carbohydrate materials have become increasingly utilized in transplantation and cell/tissue engineering within the past year. This has been well documented in recent applications of immobilized or soluble α-galactosyl epitopes (i.e. oligosaccharides with a terminal Galα1-3Gal sequence) in preventing hyperacute rejection in pig-to-primate xenotransplantation. In addition, α-galactosyl polymers have been shown to exhibit much greater activity (up to 104 times) than α-galactosyl monomers in inhibiting the binding of anti-galactosyl antibodies to pig kidney epithelial cells and assisting in the prevention of cytotoxicity in human serum.",

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AB - Carbohydrate materials have become increasingly utilized in transplantation and cell/tissue engineering within the past year. This has been well documented in recent applications of immobilized or soluble α-galactosyl epitopes (i.e. oligosaccharides with a terminal Galα1-3Gal sequence) in preventing hyperacute rejection in pig-to-primate xenotransplantation. In addition, α-galactosyl polymers have been shown to exhibit much greater activity (up to 104 times) than α-galactosyl monomers in inhibiting the binding of anti-galactosyl antibodies to pig kidney epithelial cells and assisting in the prevention of cytotoxicity in human serum.

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