Abstract
Carbohydrate materials have become increasingly utilized in transplantation and cell/tissue engineering within the past year. This has been well documented in recent applications of immobilized or soluble α-galactosyl epitopes (i.e. oligosaccharides with a terminal Galα1-3Gal sequence) in preventing hyperacute rejection in pig-to-primate xenotransplantation. In addition, α-galactosyl polymers have been shown to exhibit much greater activity (up to 104 times) than α-galactosyl monomers in inhibiting the binding of anti-galactosyl antibodies to pig kidney epithelial cells and assisting in the prevention of cytotoxicity in human serum.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 650-658 |
| Number of pages | 9 |
| Journal | Current Opinion in Chemical Biology |
| Volume | 3 |
| Issue number | 6 |
| DOIs | |
| State | Published - Dec 1 1999 |
| Externally published | Yes |
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ASJC Scopus subject areas
- Biochemistry
Cite this
Carbohydrates in transplantation. / Chen, Xi; Andreana, Peter R.; Wang, Peng George.
In: Current Opinion in Chemical Biology, Vol. 3, No. 6, 01.12.1999, p. 650-658.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Carbohydrates in transplantation
AU - Chen, Xi
AU - Andreana, Peter R.
AU - Wang, Peng George
PY - 1999/12/1
Y1 - 1999/12/1
N2 - Carbohydrate materials have become increasingly utilized in transplantation and cell/tissue engineering within the past year. This has been well documented in recent applications of immobilized or soluble α-galactosyl epitopes (i.e. oligosaccharides with a terminal Galα1-3Gal sequence) in preventing hyperacute rejection in pig-to-primate xenotransplantation. In addition, α-galactosyl polymers have been shown to exhibit much greater activity (up to 104 times) than α-galactosyl monomers in inhibiting the binding of anti-galactosyl antibodies to pig kidney epithelial cells and assisting in the prevention of cytotoxicity in human serum.
AB - Carbohydrate materials have become increasingly utilized in transplantation and cell/tissue engineering within the past year. This has been well documented in recent applications of immobilized or soluble α-galactosyl epitopes (i.e. oligosaccharides with a terminal Galα1-3Gal sequence) in preventing hyperacute rejection in pig-to-primate xenotransplantation. In addition, α-galactosyl polymers have been shown to exhibit much greater activity (up to 104 times) than α-galactosyl monomers in inhibiting the binding of anti-galactosyl antibodies to pig kidney epithelial cells and assisting in the prevention of cytotoxicity in human serum.
UR - http://www.scopus.com/inward/record.url?scp=0032707333&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0032707333&partnerID=8YFLogxK
U2 - 10.1016/S1367-5931(99)00022-8
DO - 10.1016/S1367-5931(99)00022-8
M3 - Article
C2 - 10600719
AN - SCOPUS:0032707333
VL - 3
SP - 650
EP - 658
JO - Current Opinion in Chemical Biology
JF - Current Opinion in Chemical Biology
SN - 1367-5931
IS - 6
ER -