Carbohydrates in transplantation

Xi Chen, Peter R. Andreana, Peng George Wang

Research output: Contribution to journalArticle

33 Citations (Scopus)

Abstract

Carbohydrate materials have become increasingly utilized in transplantation and cell/tissue engineering within the past year. This has been well documented in recent applications of immobilized or soluble α-galactosyl epitopes (i.e. oligosaccharides with a terminal Galα1-3Gal sequence) in preventing hyperacute rejection in pig-to-primate xenotransplantation. In addition, α-galactosyl polymers have been shown to exhibit much greater activity (up to 104 times) than α-galactosyl monomers in inhibiting the binding of anti-galactosyl antibodies to pig kidney epithelial cells and assisting in the prevention of cytotoxicity in human serum.

Original languageEnglish (US)
Pages (from-to)650-658
Number of pages9
JournalCurrent Opinion in Chemical Biology
Volume3
Issue number6
DOIs
StatePublished - Dec 1 1999
Externally publishedYes

Fingerprint

Cell engineering
Transplantation (surgical)
Cytotoxicity
Oligosaccharides
Tissue engineering
Epitopes
Polymers
Swine
Transplantation
Monomers
Carbohydrates
Cell Engineering
Heterologous Transplantation
Antibodies
Tissue Engineering
Primates
Anti-Idiotypic Antibodies
Epithelial Cells
Kidney
Serum

ASJC Scopus subject areas

  • Biochemistry

Cite this

Carbohydrates in transplantation. / Chen, Xi; Andreana, Peter R.; Wang, Peng George.

In: Current Opinion in Chemical Biology, Vol. 3, No. 6, 01.12.1999, p. 650-658.

Research output: Contribution to journalArticle

Chen, Xi ; Andreana, Peter R. ; Wang, Peng George. / Carbohydrates in transplantation. In: Current Opinion in Chemical Biology. 1999 ; Vol. 3, No. 6. pp. 650-658.
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