Abstract
Carbohydrate materials have become increasingly utilized in transplantation and cell/tissue engineering within the past year. This has been well documented in recent applications of immobilized or soluble α-galactosyl epitopes (i.e. oligosaccharides with a terminal Galα1-3Gal sequence) in preventing hyperacute rejection in pig-to-primate xenotransplantation. In addition, α-galactosyl polymers have been shown to exhibit much greater activity (up to 104 times) than α-galactosyl monomers in inhibiting the binding of anti-galactosyl antibodies to pig kidney epithelial cells and assisting in the prevention of cytotoxicity in human serum.
Original language | English (US) |
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Pages (from-to) | 650-658 |
Number of pages | 9 |
Journal | Current Opinion in Chemical Biology |
Volume | 3 |
Issue number | 6 |
DOIs | |
State | Published - Dec 1 1999 |
Externally published | Yes |
ASJC Scopus subject areas
- Biochemistry