Carbohydrate metabolism in lean and obese Zucker rats

J. Triscari, J. S. Stern, P. R. Johnson, A. C. Sullivan

Research output: Contribution to journalArticle

45 Citations (Scopus)

Abstract

Carbohydrate metabolism was evaluated in lean and obese Zucker rats. Plasma glucose concentration, renal and hepatic gluconeogenesis, and hepatic glycogen content and rates of synthesis were investigated in 2-mo and 8-mo-old animals. Mild hyperglycemia was observed in obese Zucker rats compared to lean rats and was more pronounced in males than in females. Rates of glucose disappearance were normal in both female and male rats, although there was a trend toward decreased clearance in the male. Total organ hepatic and kidney PEPCK activity and kidney glucose production were elevated in obese compared to lean rats. Total organ hepatic glycogen levels and rates of glycogen synthesis were increased significantly in obese compared to lean, the increase being greater in males than females. The mild hyperglycemia present in obese Zucker rats is not associated with delayed disappearance of intravenously administered glucose, but may be due to the increased production of glucose by whole kidney and liver.

Original languageEnglish (US)
Pages (from-to)183-189
Number of pages7
JournalMetabolism
Volume28
Issue number2
DOIs
StatePublished - 1979
Externally publishedYes

Fingerprint

Zucker Rats
Carbohydrate Metabolism
Glucose
Kidney
Liver Glycogen
Hyperglycemia
Liver
Gluconeogenesis
Glycogen

ASJC Scopus subject areas

  • Endocrinology
  • Endocrinology, Diabetes and Metabolism

Cite this

Triscari, J., Stern, J. S., Johnson, P. R., & Sullivan, A. C. (1979). Carbohydrate metabolism in lean and obese Zucker rats. Metabolism, 28(2), 183-189. https://doi.org/10.1016/0026-0495(79)90084-2

Carbohydrate metabolism in lean and obese Zucker rats. / Triscari, J.; Stern, J. S.; Johnson, P. R.; Sullivan, A. C.

In: Metabolism, Vol. 28, No. 2, 1979, p. 183-189.

Research output: Contribution to journalArticle

Triscari, J, Stern, JS, Johnson, PR & Sullivan, AC 1979, 'Carbohydrate metabolism in lean and obese Zucker rats', Metabolism, vol. 28, no. 2, pp. 183-189. https://doi.org/10.1016/0026-0495(79)90084-2
Triscari, J. ; Stern, J. S. ; Johnson, P. R. ; Sullivan, A. C. / Carbohydrate metabolism in lean and obese Zucker rats. In: Metabolism. 1979 ; Vol. 28, No. 2. pp. 183-189.
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