Capturing circulating tumor cells of hepatocellular carcinoma

Li Jun Wu, Yi Da Pan, Xiao Yu Pei, Hong Chen, Samantha Nguyen, Akshay Kashyap, Jie Liu, Jian Wu

Research output: Contribution to journalArticle

35 Scopus citations

Abstract

Early metastases of hepatocellular carcinoma (HCC) may be detected by the isolation of circulating tumor cells (CTCs) in the bloodstream. During the course of therapeutic attempts, monitoring CTC changes in patients with HCC is helpful for the efficacy assessment. Nevertheless, the markers used for the detection, such as α-feto protein, asialoglycoprotein receptor or epithelial cell adhesion molecule, CD133 or CD90, are not specific for HCC CTCs. In spite of these limitations, a timely determination of the existence of CTCs will be beneficial for the monitoring of distant metastases, the evaluation of therapeutic attempts, and the prediction of prognosis.

Original languageEnglish (US)
Pages (from-to)17-22
Number of pages6
JournalCancer Letters
Volume326
Issue number1
DOIs
StatePublished - Dec 29 2012

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Keywords

  • Cancer stem cells
  • Circulating tumor cells
  • HCC thrombus formation in the portal vein
  • Hepatocellular carcinoma
  • Tumor self-seeding

ASJC Scopus subject areas

  • Cancer Research
  • Oncology

Cite this

Wu, L. J., Pan, Y. D., Pei, X. Y., Chen, H., Nguyen, S., Kashyap, A., Liu, J., & Wu, J. (2012). Capturing circulating tumor cells of hepatocellular carcinoma. Cancer Letters, 326(1), 17-22. https://doi.org/10.1016/j.canlet.2012.07.024