Capsaicin-sensitive vagal afferent fibers do not contribute to histamine H2 receptor agonist-induced gastric acid secretion in anesthetized rats

Masashi Yoneda, Helen E Raybould

Research output: Contribution to journalArticle

10 Citations (Scopus)

Abstract

The effect of perivagal capsaicin treatment on gastric acid secretion induced by the histamine H2 receptor agonist, dimaprit dihydrochloride, and the effect of the histamine H1 receptor agonist, 2-thiazolylethylamine dihydrochloride, on gastric acid secretion were studied in acute gastric fistula rats anesthetized with urethane. The integrated secretory response for the 2 h following subcutaneous (s.c.) administration of dimaprit dihydrochloride (5-20 mg/kg) did not differ in capsaicin- compared to vehicle-treated rats. Administration of 2-thiazolylethylamine dihydrochloride (20 mg/kg s.c.) did not modify gastric acid secretion in untreated rats. The present study demonstrates that the previously reported reduction in the secretory response to histamine by perivagal capsaicin treatment is unrelated to histamine H1 or H2 receptor.

Original languageEnglish (US)
Pages (from-to)349-352
Number of pages4
JournalEuropean Journal of Pharmacology
Volume186
Issue number2-3
DOIs
StatePublished - Sep 21 1990

Fingerprint

Histamine Agonists
Capsaicin
Gastric Acid
Dimaprit
Gastric Fistula
Histamine H1 Receptors
Histamine H2 Receptors
Urethane
Histamine
2-(2-aminoethyl)thiazole

Keywords

  • Capsaicin
  • Gastric acid secretion
  • Histamine H receptor agonists
  • Histamine H receptor agonists
  • Vagus

ASJC Scopus subject areas

  • Cellular and Molecular Neuroscience
  • Pharmacology

Cite this

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abstract = "The effect of perivagal capsaicin treatment on gastric acid secretion induced by the histamine H2 receptor agonist, dimaprit dihydrochloride, and the effect of the histamine H1 receptor agonist, 2-thiazolylethylamine dihydrochloride, on gastric acid secretion were studied in acute gastric fistula rats anesthetized with urethane. The integrated secretory response for the 2 h following subcutaneous (s.c.) administration of dimaprit dihydrochloride (5-20 mg/kg) did not differ in capsaicin- compared to vehicle-treated rats. Administration of 2-thiazolylethylamine dihydrochloride (20 mg/kg s.c.) did not modify gastric acid secretion in untreated rats. The present study demonstrates that the previously reported reduction in the secretory response to histamine by perivagal capsaicin treatment is unrelated to histamine H1 or H2 receptor.",
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AU - Yoneda, Masashi

AU - Raybould, Helen E

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Y1 - 1990/9/21

N2 - The effect of perivagal capsaicin treatment on gastric acid secretion induced by the histamine H2 receptor agonist, dimaprit dihydrochloride, and the effect of the histamine H1 receptor agonist, 2-thiazolylethylamine dihydrochloride, on gastric acid secretion were studied in acute gastric fistula rats anesthetized with urethane. The integrated secretory response for the 2 h following subcutaneous (s.c.) administration of dimaprit dihydrochloride (5-20 mg/kg) did not differ in capsaicin- compared to vehicle-treated rats. Administration of 2-thiazolylethylamine dihydrochloride (20 mg/kg s.c.) did not modify gastric acid secretion in untreated rats. The present study demonstrates that the previously reported reduction in the secretory response to histamine by perivagal capsaicin treatment is unrelated to histamine H1 or H2 receptor.

AB - The effect of perivagal capsaicin treatment on gastric acid secretion induced by the histamine H2 receptor agonist, dimaprit dihydrochloride, and the effect of the histamine H1 receptor agonist, 2-thiazolylethylamine dihydrochloride, on gastric acid secretion were studied in acute gastric fistula rats anesthetized with urethane. The integrated secretory response for the 2 h following subcutaneous (s.c.) administration of dimaprit dihydrochloride (5-20 mg/kg) did not differ in capsaicin- compared to vehicle-treated rats. Administration of 2-thiazolylethylamine dihydrochloride (20 mg/kg s.c.) did not modify gastric acid secretion in untreated rats. The present study demonstrates that the previously reported reduction in the secretory response to histamine by perivagal capsaicin treatment is unrelated to histamine H1 or H2 receptor.

KW - Capsaicin

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KW - Histamine H receptor agonists

KW - Histamine H receptor agonists

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