Canine transmissible venereal tumour: A morphological and immunohistochemical study of 11 tumours in growth phase and during regression after chemotherapy

C. M. Gonzalez, Stephen M Griffey, D. K. Naydan, E. Flores, R. Cepeda, G. Cattaneo, B. R. Madewell

Research output: Contribution to journalArticle

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Abstract

Eleven dogs with canine transmissible venereal tumour (CTVT) were given vincristine sulphate chemotherapy to induce tumour regression. Biopsy specimens were collected from tumours during the growth phase, before chemotherapy, and again from the same dogs during the regression induced by chemotherapy. Laboratory assessment included cytology, histology, the number of tumour cells in relation to the number of intratumoral leucocytes, proliferative and apoptotic fractions of tumour cells, intratumoral vessel density, and fibrosis. The results revealed that during regression, tumour cell proliferation ceased, apoptosis increased, leucocytes increased (with increased proportion of T lymphocytes), tumour parenchyma collapsed around intratumoral vessels, and fibrosis increased. These results, which were similar to findings in dogs with spontaneous regression of CTVT, suggest that tumour immunity plays a role in tumour regression after modest chemotherapy. (C) 2000 Harcourt Publishers Ltd.

Original languageEnglish (US)
Pages (from-to)241-248
Number of pages8
JournalJournal of Comparative Pathology
Volume122
Issue number4
DOIs
StatePublished - Apr 2000

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Veterinary Venereal Tumors
transmissible venereal tumors
drug therapy
Canidae
Drug Therapy
neoplasms
dogs
Growth
remission
Neoplasms
fibrosis
Dogs
vincristine
Fibrosis
leukocyte count
cell biology
histology
biopsy
leukocytes
cell proliferation

ASJC Scopus subject areas

  • Pathology and Forensic Medicine
  • veterinary(all)

Cite this

Canine transmissible venereal tumour : A morphological and immunohistochemical study of 11 tumours in growth phase and during regression after chemotherapy. / Gonzalez, C. M.; Griffey, Stephen M; Naydan, D. K.; Flores, E.; Cepeda, R.; Cattaneo, G.; Madewell, B. R.

In: Journal of Comparative Pathology, Vol. 122, No. 4, 04.2000, p. 241-248.

Research output: Contribution to journalArticle

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AU - Cattaneo, G.

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