Canine non-epitheliotropic CD4-positive cutaneous T-cell lymphoma: a case report

Hitoshi Kondo, Yumiko Kagawa, Kinji Shirota, Peter F Moore, Masahiko Nagata

Research output: Contribution to journalArticle

Abstract

A 5-year-old, spayed female French Bulldog presented with multiple papules on the skin of the scapular area. Histopathological examination of punch biopsy samples revealed dense infiltration of small lymphoid cells in the superficial dermis and in areas surrounding hair follicles. Immunohistochemical analysis indicated that these cells were positive for CD3, CD4, and TCRαβ, but negative for CD1c, CD8α, CD8β, CD11c, CD20, CD45RA, CD90, MHC-II, and TCRγδ. In addition, CD45 was highly expressed, and the proliferation fraction was very low. Molecular clonality of T-cell receptor G chains yielded a clonal result. The skin lesions were surgically excised because they had progressed to the lateral front leg. Postoperative clinical course was favorable, and recurrence was not observed until the dog died in a traffic accident, approximately 1 year later.

Original languageEnglish (US)
Pages (from-to)206-209
Number of pages4
JournalVeterinary Medicine and Science
Volume5
Issue number2
DOIs
StatePublished - May 1 2019

Keywords

  • CD4 positive cells
  • cutaneous T-cell lymphoma
  • dog

ASJC Scopus subject areas

  • veterinary(all)

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