Canine intraspinal meningiomas

Imaging features, histopathologic classification, and long-term outcome in 34 dogs

Research output: Contribution to journalArticle

33 Citations (Scopus)

Abstract

Background: Meningioma is the most common primary intraspinal nervous system tumor in dogs. Clinical findings, clinicopathologic data, and treatment of these tumors have been reported sporadically, but little information is available regarding cerebrospinal fluid (CSF) analysis, histologic tumor grade, or efficacy of radiation therapy as an adjunct to cytoreductive surgery. Animals: Dogs with histologically confirmed intraspinal meningiomas (n = 34). Methods: A retrospective study of dogs with intraspinal meningiomas between 1984 and 2006 was carried out. Signalment, historical information, physical examination, clinicopathologic data, radiation therapy protocols, surgery reports, and all available images were reviewed. All tumors were histologically classified and graded as defined by the international World Health Organization classification scheme for central nervous system tumors. Results: Intraspinal mengiomas in dogs are most common in the cervical spinal cord but can be found throughout the neuraxis. Location is correlated with histologic grade, with grade I tumors more likely to be in the cervical region than grade II tumors. Myelography generally shows an intradural extramedullary compressive lesion. On magnetic resonance imaging, the masses are strongly and uniformly contrast enhancing and a dural tail often is present. CSF analysis usually shows increased protein concentration with mild to moderate mixed pleocytosis. Surgical resection is an effective means of improving neurologic status, and adjunctive radiation therapy may lead to an improved outcome. Conclusions and Clinical Importance: Biopsy is necessary for definitive diagnosis, but imaging and CSF analysis can suggest a diagnosis of meningioma. Treatment of meningiomas with surgery and radiation therapy can result in a fair to excellent prognosis.

Original languageEnglish (US)
Pages (from-to)946-953
Number of pages8
JournalJournal of Veterinary Internal Medicine
Volume22
Issue number4
DOIs
StatePublished - Jul 2008

Fingerprint

Meningioma
Canidae
image analysis
Dogs
Radiotherapy
radiotherapy
neoplasms
dogs
Cerebrospinal Fluid
cerebrospinal fluid
Neoplasms
surgery
Nervous System Neoplasms
nervous system
Central Nervous System Neoplasms
Myelography
Leukocytosis
Nervous System
Physical Examination
Tail

Keywords

  • CSF analysis
  • Radiation therapy
  • Spinal tumor
  • WHO tumor classification

ASJC Scopus subject areas

  • veterinary(all)

Cite this

@article{7021c8b730254fc1af745c85215f826f,
title = "Canine intraspinal meningiomas: Imaging features, histopathologic classification, and long-term outcome in 34 dogs",
abstract = "Background: Meningioma is the most common primary intraspinal nervous system tumor in dogs. Clinical findings, clinicopathologic data, and treatment of these tumors have been reported sporadically, but little information is available regarding cerebrospinal fluid (CSF) analysis, histologic tumor grade, or efficacy of radiation therapy as an adjunct to cytoreductive surgery. Animals: Dogs with histologically confirmed intraspinal meningiomas (n = 34). Methods: A retrospective study of dogs with intraspinal meningiomas between 1984 and 2006 was carried out. Signalment, historical information, physical examination, clinicopathologic data, radiation therapy protocols, surgery reports, and all available images were reviewed. All tumors were histologically classified and graded as defined by the international World Health Organization classification scheme for central nervous system tumors. Results: Intraspinal mengiomas in dogs are most common in the cervical spinal cord but can be found throughout the neuraxis. Location is correlated with histologic grade, with grade I tumors more likely to be in the cervical region than grade II tumors. Myelography generally shows an intradural extramedullary compressive lesion. On magnetic resonance imaging, the masses are strongly and uniformly contrast enhancing and a dural tail often is present. CSF analysis usually shows increased protein concentration with mild to moderate mixed pleocytosis. Surgical resection is an effective means of improving neurologic status, and adjunctive radiation therapy may lead to an improved outcome. Conclusions and Clinical Importance: Biopsy is necessary for definitive diagnosis, but imaging and CSF analysis can suggest a diagnosis of meningioma. Treatment of meningiomas with surgery and radiation therapy can result in a fair to excellent prognosis.",
keywords = "CSF analysis, Radiation therapy, Spinal tumor, WHO tumor classification",
author = "Petersen, {S. A.} and Beverly Sturges and Dickinson, {Peter J} and Pollard, {Rachel E} and Kass, {Philip H} and Kent, {Michael S} and Karen Vernau and Lecouteur, {Richard A} and Robert Higgins",
year = "2008",
month = "7",
doi = "10.1111/j.1939-1676.2008.0106.x",
language = "English (US)",
volume = "22",
pages = "946--953",
journal = "Journal of Veterinary Internal Medicine",
issn = "0891-6640",
publisher = "Wiley-Blackwell",
number = "4",

}

TY - JOUR

T1 - Canine intraspinal meningiomas

T2 - Imaging features, histopathologic classification, and long-term outcome in 34 dogs

AU - Petersen, S. A.

AU - Sturges, Beverly

AU - Dickinson, Peter J

AU - Pollard, Rachel E

AU - Kass, Philip H

AU - Kent, Michael S

AU - Vernau, Karen

AU - Lecouteur, Richard A

AU - Higgins, Robert

PY - 2008/7

Y1 - 2008/7

N2 - Background: Meningioma is the most common primary intraspinal nervous system tumor in dogs. Clinical findings, clinicopathologic data, and treatment of these tumors have been reported sporadically, but little information is available regarding cerebrospinal fluid (CSF) analysis, histologic tumor grade, or efficacy of radiation therapy as an adjunct to cytoreductive surgery. Animals: Dogs with histologically confirmed intraspinal meningiomas (n = 34). Methods: A retrospective study of dogs with intraspinal meningiomas between 1984 and 2006 was carried out. Signalment, historical information, physical examination, clinicopathologic data, radiation therapy protocols, surgery reports, and all available images were reviewed. All tumors were histologically classified and graded as defined by the international World Health Organization classification scheme for central nervous system tumors. Results: Intraspinal mengiomas in dogs are most common in the cervical spinal cord but can be found throughout the neuraxis. Location is correlated with histologic grade, with grade I tumors more likely to be in the cervical region than grade II tumors. Myelography generally shows an intradural extramedullary compressive lesion. On magnetic resonance imaging, the masses are strongly and uniformly contrast enhancing and a dural tail often is present. CSF analysis usually shows increased protein concentration with mild to moderate mixed pleocytosis. Surgical resection is an effective means of improving neurologic status, and adjunctive radiation therapy may lead to an improved outcome. Conclusions and Clinical Importance: Biopsy is necessary for definitive diagnosis, but imaging and CSF analysis can suggest a diagnosis of meningioma. Treatment of meningiomas with surgery and radiation therapy can result in a fair to excellent prognosis.

AB - Background: Meningioma is the most common primary intraspinal nervous system tumor in dogs. Clinical findings, clinicopathologic data, and treatment of these tumors have been reported sporadically, but little information is available regarding cerebrospinal fluid (CSF) analysis, histologic tumor grade, or efficacy of radiation therapy as an adjunct to cytoreductive surgery. Animals: Dogs with histologically confirmed intraspinal meningiomas (n = 34). Methods: A retrospective study of dogs with intraspinal meningiomas between 1984 and 2006 was carried out. Signalment, historical information, physical examination, clinicopathologic data, radiation therapy protocols, surgery reports, and all available images were reviewed. All tumors were histologically classified and graded as defined by the international World Health Organization classification scheme for central nervous system tumors. Results: Intraspinal mengiomas in dogs are most common in the cervical spinal cord but can be found throughout the neuraxis. Location is correlated with histologic grade, with grade I tumors more likely to be in the cervical region than grade II tumors. Myelography generally shows an intradural extramedullary compressive lesion. On magnetic resonance imaging, the masses are strongly and uniformly contrast enhancing and a dural tail often is present. CSF analysis usually shows increased protein concentration with mild to moderate mixed pleocytosis. Surgical resection is an effective means of improving neurologic status, and adjunctive radiation therapy may lead to an improved outcome. Conclusions and Clinical Importance: Biopsy is necessary for definitive diagnosis, but imaging and CSF analysis can suggest a diagnosis of meningioma. Treatment of meningiomas with surgery and radiation therapy can result in a fair to excellent prognosis.

KW - CSF analysis

KW - Radiation therapy

KW - Spinal tumor

KW - WHO tumor classification

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U2 - 10.1111/j.1939-1676.2008.0106.x

DO - 10.1111/j.1939-1676.2008.0106.x

M3 - Article

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EP - 953

JO - Journal of Veterinary Internal Medicine

JF - Journal of Veterinary Internal Medicine

SN - 0891-6640

IS - 4

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