Canine inflammatory myopathy: Analysis of cellular infiltrates

Marti Pumarola, Peter F Moore, G. Diane Shelton

Research output: Contribution to journalArticle

53 Scopus citations

Abstract

Inflammatory myopathies (IMs) occur relatively frequently in dogs, and, with the exception of masticatory muscle myositis (MMM), have not been characterized. This study analyzed the distribution and types of cellular infiltrates in 21 cases of generalized IM, 3 cases of focal IM (MMM), and 1 case with features of both generalized and focal IM, using a panel of monoclonal antibodies to cell surface markers. In generalized IM, mononuclear cells showed an endomysial and perimysial distribution with invasion of non-necrotic fibers similar to human IM. T lymphocytes with T-cell receptor (TCR)αβ predominated. Distinct differences were seen in MMM including prominent B-cell infiltration, dendritic cells and macrophages in greater numbers than T cells, and numerous T cells with TCRγδ. Thus, generalized IM and MMM appear to be distinct diseases with different mechanisms. Canine generalized IM may be an important animal model for human IM.

Original languageEnglish (US)
Pages (from-to)782-789
Number of pages8
JournalMuscle and Nerve
Volume29
Issue number6
DOIs
StatePublished - Jun 2004

Keywords

  • Autoimmune
  • Dogs
  • Inflammatory myopathy
  • Muscle
  • Myositis

ASJC Scopus subject areas

  • Physiology
  • Clinical Neurology
  • Cellular and Molecular Neuroscience
  • Physiology (medical)

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