Canine hepatozoonosis: Comparison of lesions and parasites in skeletal muscle of dogs experimentally or naturally infected with Hepatozoon americanum

R. J. Panciera, S. A. Ewing, J. S. Mathew, Terry W Lehenbauer, C. A. Cummings, J. P. Woods

Research output: Contribution to journalArticle

34 Citations (Scopus)

Abstract

We report previously undescribed, early lesions in skeletal muscle of dogs experimentally infected with Hepatozoon americanum by ingestion of laboratory-reared, infected Amblyomma maculatum. The earliest muscle lesion was recognized at the first interval of examination 3 weeks following exposure. The lesion consisted of a large, modified host cell whose cytoplasm frequently contained a demonstrable parasite. In skeletal muscle, the cell was consistently located between muscle fibers or in loose connective tissue adjacent to those fibers. Evidence suggesting that the parasite arrives in muscle and other tissue within the host cell cytoplasm is presented. Mucopolysaccharide encystment of the host cell, absent at this early stage, was acquired gradually and approached maximal development 26 weeks post exposure. Completion of the asexual cycle as evidenced by the presence of parasites entering vascular lumens within granulomas and also by the presence of gamonts in peripheral blood leukocytes, occurred within 28-32 days postexposure. Progression of the parasite cycle from meront to passage of zoites into vessel lumens of granulomas can occur in 11 or fewer days. The density with which parasitic lesions occur in one named skeletal muscle compared to other named muscles, although somewhat variable, was not significantly different in either experimentally induced or natural infections. The distribution of developmental stages of the parasite/lesion in four experimental infections (969 lesions) is compared with those in eight dogs with natural infections (557 lesions). Copyright (C) 1999 Elsevier Science B.V.

Original languageEnglish (US)
Pages (from-to)261-272
Number of pages12
JournalVeterinary Parasitology
Volume82
Issue number4
DOIs
StatePublished - May 1999
Externally publishedYes

Fingerprint

Hepatozoon
lesions (animal)
skeletal muscle
Canidae
Parasites
Skeletal Muscle
Dogs
parasites
dogs
Muscles
Granuloma
Cytoplasm
granuloma
Infection
muscles
cytoplasm
Amblyomma maculatum
infection
Glycosaminoglycans
Connective Tissue

Keywords

  • Experimental and natural infections
  • Hepatozoon americanum
  • Tissue stages and lesions

ASJC Scopus subject areas

  • Animal Science and Zoology
  • Parasitology
  • veterinary(all)

Cite this

Canine hepatozoonosis : Comparison of lesions and parasites in skeletal muscle of dogs experimentally or naturally infected with Hepatozoon americanum. / Panciera, R. J.; Ewing, S. A.; Mathew, J. S.; Lehenbauer, Terry W; Cummings, C. A.; Woods, J. P.

In: Veterinary Parasitology, Vol. 82, No. 4, 05.1999, p. 261-272.

Research output: Contribution to journalArticle

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