Canine distemper epizootic in lions, tigers, and leopards in North America

Max J.G. Appel, Margaret Barr, Susan Pearce-Kelling, Brian A. Summers, Rebecca A. Yates, Silvio Santinelli, George L. Foley, Jon J. Bernstein, Lucy H. Spelman, Lyle D. Miller, Lawrence H. Arp, Mark L Anderson

Research output: Contribution to journalArticle

165 Citations (Scopus)

Abstract

Canine distemper virus (CDV) infection occurred in captive leopards (Panthera pardus), tigers (Panthera tigris), lions (Panthera leo), and a jaguar (Panthera onca) in 1991 and 1992. An epizootic affected all 4 types of cats at the Wildlife Waystation, San Fernando, California, with 17 mortalities. CDV-infected raccoons were thought to be the source of infection in these cats. Two black leopards died at the Naibi Zoo, Coal Valley, Illinois, and 2 tigers died at the Shambala Preserve, Acton, California. Initial clinical signs were anorexia with gastrointestinal and/or respiratory disease followed by seizures. Canine distemper virus was isolated from 3 leopards, 3 tigers, and 3 lions that died or were euthanized when moribund. Monoclonal antibody testing identified the virus isolates as CDV. Gross and histopathologic findings were similar to those found in canids with distemper with a few exceptions. There were fewer lesions in the brain, and there was a pronounced type 2 cell proliferation in the lung, with inclusion bodies and CDV antigen demonstrated by immunohistology. Neutralizing antibody to CDV was found in high titers in serum from most animals but was absent or was found only in low titers in some cats that succumbed after CDV infection. There was a marked difference in neutralizing antibody titers when tests were done with different strains of CDV.

Original languageEnglish (US)
Pages (from-to)277-288
Number of pages12
JournalJournal of Veterinary Diagnostic Investigation
Volume6
Issue number3
DOIs
StatePublished - Jan 1 1994

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Panthera
Distemper
Canine Distemper Virus
Lions
Tigers
canine distemper
Canine distemper virus
Panthera leo
Panthera tigris
North America
Panthera onca
Cats
Virus Diseases
cats
Neutralizing Antibodies
neutralizing antibodies
Raccoons
infection
distemper
Panthera pardus

ASJC Scopus subject areas

  • veterinary(all)

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Canine distemper epizootic in lions, tigers, and leopards in North America. / Appel, Max J.G.; Barr, Margaret; Pearce-Kelling, Susan; Summers, Brian A.; Yates, Rebecca A.; Santinelli, Silvio; Foley, George L.; Bernstein, Jon J.; Spelman, Lucy H.; Miller, Lyle D.; Arp, Lawrence H.; Anderson, Mark L.

In: Journal of Veterinary Diagnostic Investigation, Vol. 6, No. 3, 01.01.1994, p. 277-288.

Research output: Contribution to journalArticle

Appel, MJG, Barr, M, Pearce-Kelling, S, Summers, BA, Yates, RA, Santinelli, S, Foley, GL, Bernstein, JJ, Spelman, LH, Miller, LD, Arp, LH & Anderson, ML 1994, 'Canine distemper epizootic in lions, tigers, and leopards in North America', Journal of Veterinary Diagnostic Investigation, vol. 6, no. 3, pp. 277-288. https://doi.org/10.1177/104063879400600301
Appel MJG, Barr M, Pearce-Kelling S, Summers BA, Yates RA, Santinelli S et al. Canine distemper epizootic in lions, tigers, and leopards in North America. Journal of Veterinary Diagnostic Investigation. 1994 Jan 1;6(3):277-288. https://doi.org/10.1177/104063879400600301
Appel, Max J.G. ; Barr, Margaret ; Pearce-Kelling, Susan ; Summers, Brian A. ; Yates, Rebecca A. ; Santinelli, Silvio ; Foley, George L. ; Bernstein, Jon J. ; Spelman, Lucy H. ; Miller, Lyle D. ; Arp, Lawrence H. ; Anderson, Mark L. / Canine distemper epizootic in lions, tigers, and leopards in North America. In: Journal of Veterinary Diagnostic Investigation. 1994 ; Vol. 6, No. 3. pp. 277-288.
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