Cancer the‘RBP'eutics–RNA-binding proteins as therapeutic targets for cancer

Shakur Mohibi; Xinbin Chen; Jin Zhang

doi:10.1016/j.pharmthera.2019.07.001

Cancer the‘RBP'eutics–RNA-binding proteins as therapeutic targets for cancer

Shakur Mohibi, Xinbin Chen, Jin Zhang

School of Veterinary Medicine

Research output: Contribution to journal › Review article › peer-review

8 Scopus citations

Abstract

RNA-binding proteins (RBPs) play a critical role in the regulation of various RNA processes, including splicing, cleavage and polyadenylation, transport, translation and degradation of coding RNAs, non-coding RNAs and microRNAs. Recent studies indicate that RBPs not only play an instrumental role in normal cellular processes but have also emerged as major players in the development and spread of cancer. Herein, we review the current knowledge about RNA binding proteins and their role in tumorigenesis as well as the potential to target RBPs for cancer therapeutics.

Original language	English (US)
Article number	107390
Journal	Pharmacology and Therapeutics
Volume	203
DOIs	https://doi.org/10.1016/j.pharmthera.2019.07.001
State	Published - Nov 2019

Keywords

Aptamer
Cancer therapeutics
Peptide
RNA-binding domains
RNA-binding proteins
siRNA
Small molecules

ASJC Scopus subject areas

Pharmacology
Pharmacology (medical)

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Cite this

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title = "Cancer the{\textquoteleft}RBP'eutics–RNA-binding proteins as therapeutic targets for cancer",

abstract = "RNA-binding proteins (RBPs) play a critical role in the regulation of various RNA processes, including splicing, cleavage and polyadenylation, transport, translation and degradation of coding RNAs, non-coding RNAs and microRNAs. Recent studies indicate that RBPs not only play an instrumental role in normal cellular processes but have also emerged as major players in the development and spread of cancer. Herein, we review the current knowledge about RNA binding proteins and their role in tumorigenesis as well as the potential to target RBPs for cancer therapeutics.",

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AU - Chen, Xinbin

AU - Zhang, Jin

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AB - RNA-binding proteins (RBPs) play a critical role in the regulation of various RNA processes, including splicing, cleavage and polyadenylation, transport, translation and degradation of coding RNAs, non-coding RNAs and microRNAs. Recent studies indicate that RBPs not only play an instrumental role in normal cellular processes but have also emerged as major players in the development and spread of cancer. Herein, we review the current knowledge about RNA binding proteins and their role in tumorigenesis as well as the potential to target RBPs for cancer therapeutics.

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KW - Cancer therapeutics

KW - Peptide

KW - RNA-binding domains

KW - RNA-binding proteins

KW - siRNA

KW - Small molecules

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