Abstract
RNA-binding proteins (RBPs) play a critical role in the regulation of various RNA processes, including splicing, cleavage and polyadenylation, transport, translation and degradation of coding RNAs, non-coding RNAs and microRNAs. Recent studies indicate that RBPs not only play an instrumental role in normal cellular processes but have also emerged as major players in the development and spread of cancer. Herein, we review the current knowledge about RNA binding proteins and their role in tumorigenesis as well as the potential to target RBPs for cancer therapeutics.
| Original language | English (US) |
|---|---|
| Article number | 107390 |
| Journal | Pharmacology and Therapeutics |
| Volume | 203 |
| DOIs | |
| State | Published - Nov 2019 |
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Keywords
- Aptamer
- Cancer therapeutics
- Peptide
- RNA-binding domains
- RNA-binding proteins
- siRNA
- Small molecules
ASJC Scopus subject areas
- Pharmacology
- Pharmacology (medical)
Cite this
Cancer the‘RBP'eutics–RNA-binding proteins as therapeutic targets for cancer. / Mohibi, Shakur; Chen, Xinbin; Zhang, Jin.
In: Pharmacology and Therapeutics, Vol. 203, 107390, 11.2019.Research output: Contribution to journal › Review article
}
TY - JOUR
T1 - Cancer the‘RBP'eutics–RNA-binding proteins as therapeutic targets for cancer
AU - Mohibi, Shakur
AU - Chen, Xinbin
AU - Zhang, Jin
PY - 2019/11
Y1 - 2019/11
N2 - RNA-binding proteins (RBPs) play a critical role in the regulation of various RNA processes, including splicing, cleavage and polyadenylation, transport, translation and degradation of coding RNAs, non-coding RNAs and microRNAs. Recent studies indicate that RBPs not only play an instrumental role in normal cellular processes but have also emerged as major players in the development and spread of cancer. Herein, we review the current knowledge about RNA binding proteins and their role in tumorigenesis as well as the potential to target RBPs for cancer therapeutics.
AB - RNA-binding proteins (RBPs) play a critical role in the regulation of various RNA processes, including splicing, cleavage and polyadenylation, transport, translation and degradation of coding RNAs, non-coding RNAs and microRNAs. Recent studies indicate that RBPs not only play an instrumental role in normal cellular processes but have also emerged as major players in the development and spread of cancer. Herein, we review the current knowledge about RNA binding proteins and their role in tumorigenesis as well as the potential to target RBPs for cancer therapeutics.
KW - Aptamer
KW - Cancer therapeutics
KW - Peptide
KW - RNA-binding domains
KW - RNA-binding proteins
KW - siRNA
KW - Small molecules
UR - http://www.scopus.com/inward/record.url?scp=85069614640&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=85069614640&partnerID=8YFLogxK
U2 - 10.1016/j.pharmthera.2019.07.001
DO - 10.1016/j.pharmthera.2019.07.001
M3 - Review article
C2 - 31302171
AN - SCOPUS:85069614640
VL - 203
JO - Pharmacology and Therapeutics
JF - Pharmacology and Therapeutics
SN - 0163-7258
M1 - 107390
ER -