Cancer the‘RBP'eutics–RNA-binding proteins as therapeutic targets for cancer

Shakur Mohibi; Xinbin Chen; Jin Zhang

doi:10.1016/j.pharmthera.2019.07.001

Cancer the‘RBP'eutics–RNA-binding proteins as therapeutic targets for cancer

Shakur Mohibi, Xinbin Chen, Jin Zhang

School of Veterinary Medicine

Research output: Contribution to journal › Review article › peer-review

19 Scopus citations

Abstract

RNA-binding proteins (RBPs) play a critical role in the regulation of various RNA processes, including splicing, cleavage and polyadenylation, transport, translation and degradation of coding RNAs, non-coding RNAs and microRNAs. Recent studies indicate that RBPs not only play an instrumental role in normal cellular processes but have also emerged as major players in the development and spread of cancer. Herein, we review the current knowledge about RNA binding proteins and their role in tumorigenesis as well as the potential to target RBPs for cancer therapeutics.

Original language	English (US)
Article number	107390
Journal	Pharmacology and Therapeutics
Volume	203
DOIs	https://doi.org/10.1016/j.pharmthera.2019.07.001
State	Published - Nov 2019

Keywords

Aptamer
Cancer therapeutics
Peptide
RNA-binding domains
RNA-binding proteins
siRNA
Small molecules

ASJC Scopus subject areas

Pharmacology
Pharmacology (medical)

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title = "Cancer the{\textquoteleft}RBP'eutics–RNA-binding proteins as therapeutic targets for cancer",

abstract = "RNA-binding proteins (RBPs) play a critical role in the regulation of various RNA processes, including splicing, cleavage and polyadenylation, transport, translation and degradation of coding RNAs, non-coding RNAs and microRNAs. Recent studies indicate that RBPs not only play an instrumental role in normal cellular processes but have also emerged as major players in the development and spread of cancer. Herein, we review the current knowledge about RNA binding proteins and their role in tumorigenesis as well as the potential to target RBPs for cancer therapeutics.",

keywords = "Aptamer, Cancer therapeutics, Peptide, RNA-binding domains, RNA-binding proteins, siRNA, Small molecules",

author = "Shakur Mohibi and Xinbin Chen and Jin Zhang",

year = "2019",

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language = "English (US)",

volume = "203",

journal = "Pharmacology and Therapeutics",

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T1 - Cancer the‘RBP'eutics–RNA-binding proteins as therapeutic targets for cancer

AU - Mohibi, Shakur

AU - Chen, Xinbin

AU - Zhang, Jin

PY - 2019/11

Y1 - 2019/11

N2 - RNA-binding proteins (RBPs) play a critical role in the regulation of various RNA processes, including splicing, cleavage and polyadenylation, transport, translation and degradation of coding RNAs, non-coding RNAs and microRNAs. Recent studies indicate that RBPs not only play an instrumental role in normal cellular processes but have also emerged as major players in the development and spread of cancer. Herein, we review the current knowledge about RNA binding proteins and their role in tumorigenesis as well as the potential to target RBPs for cancer therapeutics.

AB - RNA-binding proteins (RBPs) play a critical role in the regulation of various RNA processes, including splicing, cleavage and polyadenylation, transport, translation and degradation of coding RNAs, non-coding RNAs and microRNAs. Recent studies indicate that RBPs not only play an instrumental role in normal cellular processes but have also emerged as major players in the development and spread of cancer. Herein, we review the current knowledge about RNA binding proteins and their role in tumorigenesis as well as the potential to target RBPs for cancer therapeutics.

KW - Aptamer

KW - Cancer therapeutics

KW - Peptide

KW - RNA-binding domains

KW - RNA-binding proteins

KW - siRNA

KW - Small molecules

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DO - 10.1016/j.pharmthera.2019.07.001

M3 - Review article

C2 - 31302171

AN - SCOPUS:85069614640

VL - 203

JO - Pharmacology and Therapeutics

JF - Pharmacology and Therapeutics

SN - 0163-7258

M1 - 107390

ER -

Cancer the‘RBP'eutics–RNA-binding proteins as therapeutic targets for cancer

Abstract

Keywords

ASJC Scopus subject areas

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