Cancer the‘RBP'eutics–RNA-binding proteins as therapeutic targets for cancer

Shakur Mohibi, Xinbin Chen, Jin Zhang

Research output: Contribution to journalReview article

Abstract

RNA-binding proteins (RBPs) play a critical role in the regulation of various RNA processes, including splicing, cleavage and polyadenylation, transport, translation and degradation of coding RNAs, non-coding RNAs and microRNAs. Recent studies indicate that RBPs not only play an instrumental role in normal cellular processes but have also emerged as major players in the development and spread of cancer. Herein, we review the current knowledge about RNA binding proteins and their role in tumorigenesis as well as the potential to target RBPs for cancer therapeutics.

Original languageEnglish (US)
Article number107390
JournalPharmacology and Therapeutics
Volume203
DOIs
StatePublished - Nov 2019

Fingerprint

RNA-Binding Proteins
Carrier Proteins
Neoplasms
Untranslated RNA
Polyadenylation
Therapeutics
MicroRNAs
Carcinogenesis
RNA

Keywords

  • Aptamer
  • Cancer therapeutics
  • Peptide
  • RNA-binding domains
  • RNA-binding proteins
  • siRNA
  • Small molecules

ASJC Scopus subject areas

  • Pharmacology
  • Pharmacology (medical)

Cite this

Cancer the‘RBP'eutics–RNA-binding proteins as therapeutic targets for cancer. / Mohibi, Shakur; Chen, Xinbin; Zhang, Jin.

In: Pharmacology and Therapeutics, Vol. 203, 107390, 11.2019.

Research output: Contribution to journalReview article

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