Abstract
In clinic, tumor recurrence and metastasis are the major barriers to further improve the overall cancer patients’ survival. The theory of tumor repopulation due to radiation described decades ago is being supported by new experimental data. The heterogeneity of cancer cell populations in a given tumor is recently evidenced by the present of cancer stem cells (CSCs) that are different from other non-CSC tumor cells and maintain unique self-renewal and tumor-initiating phenotypes. The CSCs isolated from many human tumors including the breast cancer stem cells (BCSCs) are demonstrated to hold specific characteristics and are demonstrated to be resistant to an array of anti-cancer agents and radiation therapy. In this chapter, a number of prosurvival pathways and biomarkers found in BCSCs will be discussed. Several prosurvival features including CSCs repopulation, DNA repair ability, as well as the HER2- NFjB-HER2 signaling loop in the radioresistant BCSCs will be illustrated. Further clarification of the specific networks associated with the radioresistant phenotype of BCSCs will shed new light on the molecular mechanism of tumor radioresistance, and will help to generate targets to detect and treat therapy-resistant tumor cells.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 49-57 |
| Number of pages | 9 |
| Journal | Medical radiology |
| Volume | 63 |
| DOIs | |
| State | Published - 2012 |
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ASJC Scopus subject areas
- Radiology Nuclear Medicine and imaging
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Cancer stem cells and radiotherapy. / Li, Jian-Jian.
In: Medical radiology, Vol. 63, 2012, p. 49-57.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Cancer stem cells and radiotherapy
AU - Li, Jian-Jian
PY - 2012
Y1 - 2012
N2 - In clinic, tumor recurrence and metastasis are the major barriers to further improve the overall cancer patients’ survival. The theory of tumor repopulation due to radiation described decades ago is being supported by new experimental data. The heterogeneity of cancer cell populations in a given tumor is recently evidenced by the present of cancer stem cells (CSCs) that are different from other non-CSC tumor cells and maintain unique self-renewal and tumor-initiating phenotypes. The CSCs isolated from many human tumors including the breast cancer stem cells (BCSCs) are demonstrated to hold specific characteristics and are demonstrated to be resistant to an array of anti-cancer agents and radiation therapy. In this chapter, a number of prosurvival pathways and biomarkers found in BCSCs will be discussed. Several prosurvival features including CSCs repopulation, DNA repair ability, as well as the HER2- NFjB-HER2 signaling loop in the radioresistant BCSCs will be illustrated. Further clarification of the specific networks associated with the radioresistant phenotype of BCSCs will shed new light on the molecular mechanism of tumor radioresistance, and will help to generate targets to detect and treat therapy-resistant tumor cells.
AB - In clinic, tumor recurrence and metastasis are the major barriers to further improve the overall cancer patients’ survival. The theory of tumor repopulation due to radiation described decades ago is being supported by new experimental data. The heterogeneity of cancer cell populations in a given tumor is recently evidenced by the present of cancer stem cells (CSCs) that are different from other non-CSC tumor cells and maintain unique self-renewal and tumor-initiating phenotypes. The CSCs isolated from many human tumors including the breast cancer stem cells (BCSCs) are demonstrated to hold specific characteristics and are demonstrated to be resistant to an array of anti-cancer agents and radiation therapy. In this chapter, a number of prosurvival pathways and biomarkers found in BCSCs will be discussed. Several prosurvival features including CSCs repopulation, DNA repair ability, as well as the HER2- NFjB-HER2 signaling loop in the radioresistant BCSCs will be illustrated. Further clarification of the specific networks associated with the radioresistant phenotype of BCSCs will shed new light on the molecular mechanism of tumor radioresistance, and will help to generate targets to detect and treat therapy-resistant tumor cells.
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U2 - 10.1007/174_2012_648
DO - 10.1007/174_2012_648
M3 - Article
AN - SCOPUS:84929086783
VL - 63
SP - 49
EP - 57
JO - Medical radiology
JF - Medical radiology
SN - 0942-5373
ER -