Cancer specific survival in patients with sickle cell disease

Ann Brunson, Theresa H Keegan, Anjlee Mahajan, Susan Paulukonis, Theodore Wun

Research output: Contribution to journalArticle

1 Scopus citations

Abstract

Sickle cell disease (SCD) patients have a higher incidence of certain cancers, but no studies have determined the impact of cancer on survival among SCD patients. SCD patients (n = 6423), identified from state-wide hospitalisation data, were linked to the California Cancer Registry (1988–2014). Multivariable Cox proportional hazards regression was used to examine survival. Among SCD patients, a cancer diagnosis was associated with a 3-fold increased hazard of death. Compared to matched cancer patients without SCD, SCD was associated with worse overall survival, but not cancer-specific survival, suggesting that SCD cancer patients should be treated with similar therapeutic intent.

Original languageEnglish (US)
JournalBritish Journal of Haematology
DOIs
StateAccepted/In press - Jan 1 2018

Keywords

  • cancer
  • epidemiology
  • Sickle cell disease
  • survival

ASJC Scopus subject areas

  • Hematology

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