Can OCT angiography be made a quantitative blood measurement tool?

Jun Zhu, Conrad W. Merkle, Marcel T. Bernucci, Shau Poh Chong, Vivek Srinivasan

Research output: Contribution to journalArticlepeer-review

18 Scopus citations


Optical Coherence Tomography Angiography (OCTA) refers to a powerful class of OCT scanning protocols and algorithms that selectively enhance the imaging of blood vessel lumens, based mainly on the motion and scattering of red blood cells (RBCs). Though OCTA is widely used in clinical and basic science applications for visualization of perfused blood vessels, OCTA is still primarily a qualitative tool. However, more quantitative hemodynamic information would better delineate disease mechanisms, and potentially improve the sensitivity for detecting early stages of disease. Here, we take a broader view of OCTA in the context of microvascular hemodynamics and light scattering. Paying particular attention to the unique challenges presented by capillaries versus larger supplying and draining vessels, we critically assess opportunities and challenges in making OCTA a quantitative tool.

Original languageEnglish (US)
Article number687
JournalApplied Sciences (Switzerland)
Issue number7
StatePublished - Jul 4 2017


  • Angiography
  • Blood flow
  • Hemodynamics
  • Imaging
  • Optical coherence tomography
  • Red blood cells
  • Rheology
  • Scattering

ASJC Scopus subject areas

  • Materials Science(all)
  • Instrumentation
  • Engineering(all)
  • Process Chemistry and Technology
  • Computer Science Applications
  • Fluid Flow and Transfer Processes


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