Can metabolomics be used for assessing nutritive-dependent human diseases?

Oliver Fiehn, Joachim Spranger

Research output: Contribution to journalArticle

2 Scopus citations

Abstract

Metabolomic approaches are taking place within emerging technologies that share the focus to unravel unexpected effects in classical biological experiments, for example mutant/wild type comparisons. This review highlights the possibility of metabolomics going beyond this stage and comparing the onset and the pathogenesis of complex diseases, such as type 2 diabetes mellitus, in large scale projects that might reach out to compare different populations and different nutritional diets and interventions. The steps of validation that are needed to pursue such projects are described, and the range of analytical and computational approaches that can be utilized are discussed. Using type 2 diabetes mellitus, it is emphasized that there is a high economic and scientific need to reliably diagnose and predict metabolic diseases in a cost effective manner.

Original languageEnglish (US)
Pages (from-to)223-230
Number of pages8
JournalPhytochemistry Reviews
Volume1
Issue number2
DOIs
StatePublished - 2002
Externally publishedYes

Keywords

  • Diabetes mellitus
  • Mass spectrometry
  • Metabolomics
  • Pattern recognition

ASJC Scopus subject areas

  • Molecular Medicine
  • Plant Science
  • Biotechnology

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