TY - JOUR
T1 - Can dietary intake patterns account for the familial aggregation of disease? Evidence from adult siblings living apart
AU - Sellers, T. A.
AU - Kushi, L. H.
AU - Potter, J. D.
PY - 1991
Y1 - 1991
N2 - The familial aggregation of certain chronic diseases is well documented [Perkins, 1986; King et al., 1984; Anderson, 1982]. Dietary data on adult brothers living apart were used to examine whether familial clustering of disease could be explained by nature or nutriture. Intakes of nutrients were strikingly more similar among siblings than expected: when correlations were adjusted for country of residence, 21 of 25 (84%) were statistically significant. Thus, dietary patterns among adult siblings are more alike than could be predicted by their sharing a common culture, as alike as has been described for monozygotic twins, and as alike as described for familial correlations of serum cholesterol. Incorporation of dietary measures in co-twin studies or studies of siblings can improve the estimates of the true genetic effect on disease pathogenesis.
AB - The familial aggregation of certain chronic diseases is well documented [Perkins, 1986; King et al., 1984; Anderson, 1982]. Dietary data on adult brothers living apart were used to examine whether familial clustering of disease could be explained by nature or nutriture. Intakes of nutrients were strikingly more similar among siblings than expected: when correlations were adjusted for country of residence, 21 of 25 (84%) were statistically significant. Thus, dietary patterns among adult siblings are more alike than could be predicted by their sharing a common culture, as alike as has been described for monozygotic twins, and as alike as described for familial correlations of serum cholesterol. Incorporation of dietary measures in co-twin studies or studies of siblings can improve the estimates of the true genetic effect on disease pathogenesis.
UR - http://www.scopus.com/inward/record.url?scp=0025894806&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0025894806&partnerID=8YFLogxK
M3 - Article
C2 - 1916234
AN - SCOPUS:0025894806
VL - 8
SP - 105
EP - 112
JO - Genetic Epidemiology
JF - Genetic Epidemiology
SN - 0741-0395
IS - 2
ER -