CaMKII hunkers down on the muscarinic M4 receptor to help curb cocaine-induced hyperlocomotion

Ivar S. Stein; Johannes W Hell

doi:10.1038/emboj.2010.105

CaMKII hunkers down on the muscarinic M4 receptor to help curb cocaine-induced hyperlocomotion

Ivar S. Stein, Johannes W Hell

Pharmacology

Research output: Contribution to journal › Article › peer-review

4 Scopus citations

Abstract

The dopaminergic receptor D1 activates and the muscarinic acetylcholine receptor (mAChR) M4 inhibits adenylyl cyclase (AC) and thereby cAMP production through the trimeric Gα_s and Gα_i/o proteins, respectively (Wess et al, 2007). D1 and M4 are coexpressed in striatal output neurons, where M4 antagonizes D1 signalling as recently pinpointed by conditional M4 knockout in D1-expressing neurons (Jeon et al, 2010). Closely following on the heels of this article, Guo et al (2010) report in this issue that CaMKII binds and phosphorylates M4 upon Ca²⁺ influx to augment the antagonistic action of M4 on D1 signalling and on D1-mediated, cocaine-triggered hyperlocomotion.

Original language	English (US)
Pages (from-to)	1943-1945
Number of pages	3
Journal	EMBO Journal
Volume	29
Issue number	12
DOIs	https://doi.org/10.1038/emboj.2010.105
State	Published - Jun 16 2010

ASJC Scopus subject areas

Molecular Biology
Biochemistry, Genetics and Molecular Biology(all)
Immunology and Microbiology(all)
Neuroscience(all)

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title = "CaMKII hunkers down on the muscarinic M4 receptor to help curb cocaine-induced hyperlocomotion",

abstract = "The dopaminergic receptor D1 activates and the muscarinic acetylcholine receptor (mAChR) M4 inhibits adenylyl cyclase (AC) and thereby cAMP production through the trimeric Gαs and Gαi/o proteins, respectively (Wess et al, 2007). D1 and M4 are coexpressed in striatal output neurons, where M4 antagonizes D1 signalling as recently pinpointed by conditional M4 knockout in D1-expressing neurons (Jeon et al, 2010). Closely following on the heels of this article, Guo et al (2010) report in this issue that CaMKII binds and phosphorylates M4 upon Ca2+ influx to augment the antagonistic action of M4 on D1 signalling and on D1-mediated, cocaine-triggered hyperlocomotion.",

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