CaMKII: Claiming center stage in postsynaptic function and organization

Research output: Contribution to journalArticle

138 Citations (Scopus)

Abstract

While CaMKII has long been known to be essential for synaptic plasticity and learning, recent work points to new dimensions of CaMKII function in the nervous system, revealing that CaMKII also plays an important role in synaptic organization. Ca2+-triggered autophosphorylation of CaMKII not only provides molecular memory by prolonging CaMKII activity during long-term plasticity (LTP) and learning but also represents a mechanism for autoactivation of CaMKII's multifaceted protein-docking functions. New details are also emerging about the distinct roles of CaMKIIα and CaMKIIβ in synaptic homeostasis, further illustrating the multilayered and complex nature of CaMKII's involvement in synaptic regulation. Here, I review novel molecular and functional insight into how CaMKII supports synaptic function.

Original languageEnglish (US)
Pages (from-to)249-265
Number of pages17
JournalNeuron
Volume81
Issue number2
DOIs
StatePublished - Jan 22 2014

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Calcium-Calmodulin-Dependent Protein Kinase Type 2
Learning
Neuronal Plasticity
Nervous System
Homeostasis

ASJC Scopus subject areas

  • Neuroscience(all)

Cite this

CaMKII : Claiming center stage in postsynaptic function and organization. / Hell, Johannes W.

In: Neuron, Vol. 81, No. 2, 22.01.2014, p. 249-265.

Research output: Contribution to journalArticle

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