Calorie restriction and the nutrient sensing signaling pathways

I. Dilova, E. Easlon, S. J. Lin

Research output: Contribution to journalArticlepeer-review

59 Scopus citations

Abstract

Calorie restriction (CR) is the most potent regimen known to extend the life span in multiple species. CR has also been shown to ameliorate several age-associated disorders in mammals and perhaps humans. CR induces diverse metabolic changes in organisms, and it is currently unclear whether and how these metabolic changes lead to life span extension. Recent studies in model systems have provided insight into the molecular mechanisms by which CR extends life span. In this review, we summarize and provide recent updates on multiple nutrient signaling pathways that have been connected to CR and longevity regulation. The roles of highly conserved longevity regulators - the Sirtuin family - in CR are also discussed.

Original languageEnglish (US)
Pages (from-to)752-767
Number of pages16
JournalCellular and Molecular Life Sciences
Volume64
Issue number6
DOIs
StatePublished - Mar 2007

Keywords

  • Aging
  • Akt/PKB
  • Calorie restriction
  • Insulin/PI3K
  • Mitochondria
  • Sir2
  • TOR

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)
  • Cell Biology

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