Call for a California Coccidioidomycosis Consortium to Face the Top Ten Challenges Posed by a Recalcitrant Regional Disease

George Richard Thompson, David A. Stevens, Karl V. Clemons, Josh Fierer, Royce H. Johnson, Jane E Sykes, George Rutherford, Michael Peterson, John W. Taylor, Vishnu Chaturvedi

Research output: Contribution to journalArticle

16 Scopus citations

Abstract

Coccidioidomycosis (‘Valley Fever’), caused by the inhalation of the fungus Coccidioides, remains a recalcitrant health problem in large parts of California. The incidence and severity of the disease continues to rise in many parts of the state. In this manuscript, we highlight unanswered questions about the disease. Specifically, the extent of disease burden, genetic determinants of host susceptibility, diagnostic and treatment guidelines, natural reservoirs of the pathogens, antifungal drug resistance, and fungal determinants of mild or severe disease are all areas awaiting in depth investigations. We also recommend establishment of a California Coccidioidomycosis Registry to improve clinical care and translational research.

Original languageEnglish (US)
Pages (from-to)1-9
Number of pages9
JournalMycopathologia
Volume179
Issue number1-2
DOIs
StatePublished - 2015

Keywords

  • Coccidioides
  • Coccidioidomycosis
  • Emerging infectious diseases
  • Epidemiology
  • Valley fever

ASJC Scopus subject areas

  • Plant Science
  • Agronomy and Crop Science
  • Applied Microbiology and Biotechnology
  • Microbiology
  • veterinary (miscalleneous)

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    Thompson, G. R., Stevens, D. A., Clemons, K. V., Fierer, J., Johnson, R. H., Sykes, J. E., Rutherford, G., Peterson, M., Taylor, J. W., & Chaturvedi, V. (2015). Call for a California Coccidioidomycosis Consortium to Face the Top Ten Challenges Posed by a Recalcitrant Regional Disease. Mycopathologia, 179(1-2), 1-9. https://doi.org/10.1007/s11046-014-9816-7