Calixarenes as amino acid sensors

Michele Stone, Andreas H. Franz, Carlito B Lebrilla

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Abstract

The gas-phase chemistry of calixarene-amino acid complexes was studied. The modified calix[6]arene was shown to bind strongly to amino acids to produce gas-phase complexes that withstand the matrix-assisted laser desorption/ionization (MALDI) process. Amino acid solutions were prepared at a concentration of 100 mg/mL in water. Molecular modeling calculations indicates that the more basic amino acids forms stable inclusion complexes under temperature annealing conditions whereas the less basic amino acids are not stable under the same conditions.

Original languageEnglish (US)
Title of host publicationProceedings 50th ASMS Conference on Mass Spectrometry and Allied Topics
Pages425-426
Number of pages2
StatePublished - 2002
EventProceedings - 50th ASMS Conference on Mass Spectrometry and Allied Topics - Orlando, FL, United States
Duration: Jun 2 2002Jun 6 2002

Other

OtherProceedings - 50th ASMS Conference on Mass Spectrometry and Allied Topics
CountryUnited States
CityOrlando, FL
Period6/2/026/6/02

ASJC Scopus subject areas

  • Spectroscopy

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  • Cite this

    Stone, M., Franz, A. H., & Lebrilla, C. B. (2002). Calixarenes as amino acid sensors. In Proceedings 50th ASMS Conference on Mass Spectrometry and Allied Topics (pp. 425-426)