Calcium/calmodulin-dependent kinase II regulation of cardiac ion channels

Donald M Bers; Eleonora Grandi

doi:10.1097/FJC.0b013e3181a25078

Calcium/calmodulin-dependent kinase II regulation of cardiac ion channels

Donald M Bers, Eleonora Grandi

Pharmacology

Research output: Contribution to journal › Article › peer-review

96 Scopus citations

Abstract

Calcium/calmodulin-dependent kinase II (CaMKII) is a multifunctional serine/threonine kinase expressed abundantly in the heart. CaMKII targets numerous proteins involved in excitation-contraction coupling and excitability, and its activation may simultaneously contribute to heart failure and cardiac arrhythmias. In this review, we summarize the modulatory effects of CaMKII on cardiac ion channel function and expression and illustrate potential implications in the onset of arrhythmias via a computer model.

Original language	English (US)
Pages (from-to)	180-187
Number of pages	8
Journal	Journal of Cardiovascular Pharmacology
Volume	54
Issue number	3
DOIs	https://doi.org/10.1097/FJC.0b013e3181a25078
State	Published - Sep 2009

Keywords

Arrhythmia
CaM kinase
Computer modeling
Heart failure
Ion channels

ASJC Scopus subject areas

Pharmacology
Cardiology and Cardiovascular Medicine

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10.1097/FJC.0b013e3181a25078

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