Calcium supplementation does not alter lipid oxidation or lipolysis in overweight/obese women

Vanitha Sampath, Peter J Havel, Janet C. King

Research output: Contribution to journalArticle

11 Citations (Scopus)

Abstract

Based on cell culture and studies in mice, increased dietary calcium appears to stimulate lipolysis and could possibly reduce body adiposity through hormonal influences on adipocyte calcium uptake. In this study, we investigated the effects of 1,500 mg supplemental calcium daily for 3 months on hormones regulating calcium and energy metabolism and rates of lipid oxidation and lipolysis in overweight women. Fifteen overweight (BMI > 25 kg/m2) premenopausal women were supplemented with 1,500 mg of calcium, as CaCO 3, per day for 3 months while maintaining their usual diets and activity levels. Baseline and endpoint measurements were obtained after the subjects consumed a standardized 25% fat diet for 4 days. Lipid oxidation was measured by indirect calorimetry, lipolysis by infusion of deuterated glycerol, and body fat by dual-energy X-ray absorptiometry. Urinary calcium, circulating levels of hormones involved in energy and lipid metabolism (insulin, leptin, and adiponectin) or calcium metabolism (25(OH)D, 1,25(OH)2D), and parathyroid hormone (PTH)) were also measured. Urinary levels of calcium (P = 0.005) increased and 1,25(OH)2D declined (P = 0.03). However other parameters, including body weight, body fat, PTH, insulin, leptin, adiponectin, 25(OH)D, as well as rates of lipid oxidation and lipolysis were not altered by calcium supplementation. Calcium supplementation for 3 months increased urinary calcium excretion, decreased circulating levels of 1,25(OH)2-D, but had no effect on rates of lipid oxidation or lipolysis, in these overweight women.

Original languageEnglish (US)
Pages (from-to)2400-2404
Number of pages5
JournalObesity
Volume16
Issue number11
DOIs
StatePublished - Nov 2008

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Lipolysis
Calcium
Lipids
Adiponectin
Leptin
Parathyroid Hormone
Energy Metabolism
Adipose Tissue
Hormones
Insulin
Diet
Dietary Calcium
Indirect Calorimetry
Photon Absorptiometry
Adiposity
Lipid Metabolism
Adipocytes
Glycerol
Cell Culture Techniques
Fats

ASJC Scopus subject areas

  • Endocrinology
  • Medicine (miscellaneous)
  • Endocrinology, Diabetes and Metabolism
  • Nutrition and Dietetics

Cite this

Calcium supplementation does not alter lipid oxidation or lipolysis in overweight/obese women. / Sampath, Vanitha; Havel, Peter J; King, Janet C.

In: Obesity, Vol. 16, No. 11, 11.2008, p. 2400-2404.

Research output: Contribution to journalArticle

Sampath, Vanitha ; Havel, Peter J ; King, Janet C. / Calcium supplementation does not alter lipid oxidation or lipolysis in overweight/obese women. In: Obesity. 2008 ; Vol. 16, No. 11. pp. 2400-2404.
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