Calcium signaling in skeletal muscle development, maintenance and regeneration

Michelle K. Tu, Jacqueline B. Levin, Andrew M. Hamilton, Laura N Borodinsky

Research output: Contribution to journalReview articlepeer-review

77 Scopus citations


Skeletal muscle-specific stem cells are pivotal for tissue development and regeneration. Muscle plasticity, inherent in these processes, is also essential for daily life activities. Great advances and efforts have been made in understanding the function of the skeletal muscle-dedicated stem cells, called muscle satellite cells, and the specific signaling mechanisms that activate them for recruitment in the repair of the injured muscle. Elucidating these signaling mechanisms may contribute to devising therapies for muscular injury or disease. Here we review the studies that have contributed to our understanding of how calcium signaling regulates skeletal muscle development, homeostasis and regeneration, with a focus on the calcium dynamics and calcium-dependent effectors that participate in these processes.

Original languageEnglish (US)
Pages (from-to)91-97
Number of pages7
JournalCell Calcium
Issue number2-3
StatePublished - Mar 1 2016


  • Calcineurin
  • Calcium signaling
  • Muscle hypertrophy
  • Muscle regeneration
  • Muscle satellite cells
  • Muscle wasting
  • Ryanodine receptors
  • Skeletal muscle

ASJC Scopus subject areas

  • Cell Biology
  • Molecular Biology
  • Physiology


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