Calcium signaling in cardiac ventricular myocytes

Donald M Bers, Tao Guo

Research output: Contribution to journalArticle

120 Citations (Scopus)

Abstract

Calcium (Ca) is a multifunctional regulator of diverse cellular functions. In cardiac muscle Ca is a direct central mediator of electrical activation, ion channel gating, and excitation-contraction (E-C) coupling that all occur on the millisecond time scale. The key amplification step in E-C coupling is under tight control of very local [Ca]. Ca also directly activates signaling via kinases and phosphatases (e.g., Ca-calmodulin-dependent protein kinase [CaMKII] and calcineurin) that occur over a longer time scale (seconds to minutes), and the co-localization of these Ca-dependent modulators to their targets and to Ca is also critical in distinct signaling pathways. Finally, Ca-dependent signaling is also involved in long-term (minutes to hours/days) alterations in gene expression (or excitation-transcription coupling). These pathways are involved in hypertrophy and heart failure, and they can alter the expression of some of the key Ca regulatory proteins involved in E-C coupling and their regulation by kinases and phosphatases. There may again be physical microenvironments involved in this nuclear transcription, such that they sense a discrete Ca signal that is distinct from that involved in E-C coupling. In this way cells can use Ca signaling in multiple ways that function in spatially and temporally distinct manners.

Original languageEnglish (US)
Pages (from-to)86-98
Number of pages13
JournalAnnals of the New York Academy of Sciences
Volume1047
DOIs
StatePublished - 2005
Externally publishedYes

Fingerprint

Calcium Signaling
Cardiac Myocytes
Calcium
Excitation Contraction Coupling
Phosphoric Monoester Hydrolases
Transcription
Ion Channel Gating
Phosphotransferases
Calcium-Calmodulin-Dependent Protein Kinase Type 2
Calcium-Calmodulin-Dependent Protein Kinases
Calcineurin
Hypertrophy
Myocardium
Ion Channels
Gene expression
Heart Failure
Modulators
Amplification
Muscle
Gene Expression

Keywords

  • Calcium
  • Calmodulin
  • Coupling
  • Dependent protein kinase
  • Excitation-contraction coupling

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)
  • History and Philosophy of Science

Cite this

Calcium signaling in cardiac ventricular myocytes. / Bers, Donald M; Guo, Tao.

In: Annals of the New York Academy of Sciences, Vol. 1047, 2005, p. 86-98.

Research output: Contribution to journalArticle

@article{e0502a8f7a4c40cb8bfe80779ee0fe9a,
title = "Calcium signaling in cardiac ventricular myocytes",
abstract = "Calcium (Ca) is a multifunctional regulator of diverse cellular functions. In cardiac muscle Ca is a direct central mediator of electrical activation, ion channel gating, and excitation-contraction (E-C) coupling that all occur on the millisecond time scale. The key amplification step in E-C coupling is under tight control of very local [Ca]. Ca also directly activates signaling via kinases and phosphatases (e.g., Ca-calmodulin-dependent protein kinase [CaMKII] and calcineurin) that occur over a longer time scale (seconds to minutes), and the co-localization of these Ca-dependent modulators to their targets and to Ca is also critical in distinct signaling pathways. Finally, Ca-dependent signaling is also involved in long-term (minutes to hours/days) alterations in gene expression (or excitation-transcription coupling). These pathways are involved in hypertrophy and heart failure, and they can alter the expression of some of the key Ca regulatory proteins involved in E-C coupling and their regulation by kinases and phosphatases. There may again be physical microenvironments involved in this nuclear transcription, such that they sense a discrete Ca signal that is distinct from that involved in E-C coupling. In this way cells can use Ca signaling in multiple ways that function in spatially and temporally distinct manners.",
keywords = "Calcium, Calmodulin, Coupling, Dependent protein kinase, Excitation-contraction coupling",
author = "Bers, {Donald M} and Tao Guo",
year = "2005",
doi = "10.1196/annals.1341.008",
language = "English (US)",
volume = "1047",
pages = "86--98",
journal = "Annals of the New York Academy of Sciences",
issn = "0077-8923",
publisher = "Wiley-Blackwell",

}

TY - JOUR

T1 - Calcium signaling in cardiac ventricular myocytes

AU - Bers, Donald M

AU - Guo, Tao

PY - 2005

Y1 - 2005

N2 - Calcium (Ca) is a multifunctional regulator of diverse cellular functions. In cardiac muscle Ca is a direct central mediator of electrical activation, ion channel gating, and excitation-contraction (E-C) coupling that all occur on the millisecond time scale. The key amplification step in E-C coupling is under tight control of very local [Ca]. Ca also directly activates signaling via kinases and phosphatases (e.g., Ca-calmodulin-dependent protein kinase [CaMKII] and calcineurin) that occur over a longer time scale (seconds to minutes), and the co-localization of these Ca-dependent modulators to their targets and to Ca is also critical in distinct signaling pathways. Finally, Ca-dependent signaling is also involved in long-term (minutes to hours/days) alterations in gene expression (or excitation-transcription coupling). These pathways are involved in hypertrophy and heart failure, and they can alter the expression of some of the key Ca regulatory proteins involved in E-C coupling and their regulation by kinases and phosphatases. There may again be physical microenvironments involved in this nuclear transcription, such that they sense a discrete Ca signal that is distinct from that involved in E-C coupling. In this way cells can use Ca signaling in multiple ways that function in spatially and temporally distinct manners.

AB - Calcium (Ca) is a multifunctional regulator of diverse cellular functions. In cardiac muscle Ca is a direct central mediator of electrical activation, ion channel gating, and excitation-contraction (E-C) coupling that all occur on the millisecond time scale. The key amplification step in E-C coupling is under tight control of very local [Ca]. Ca also directly activates signaling via kinases and phosphatases (e.g., Ca-calmodulin-dependent protein kinase [CaMKII] and calcineurin) that occur over a longer time scale (seconds to minutes), and the co-localization of these Ca-dependent modulators to their targets and to Ca is also critical in distinct signaling pathways. Finally, Ca-dependent signaling is also involved in long-term (minutes to hours/days) alterations in gene expression (or excitation-transcription coupling). These pathways are involved in hypertrophy and heart failure, and they can alter the expression of some of the key Ca regulatory proteins involved in E-C coupling and their regulation by kinases and phosphatases. There may again be physical microenvironments involved in this nuclear transcription, such that they sense a discrete Ca signal that is distinct from that involved in E-C coupling. In this way cells can use Ca signaling in multiple ways that function in spatially and temporally distinct manners.

KW - Calcium

KW - Calmodulin

KW - Coupling

KW - Dependent protein kinase

KW - Excitation-contraction coupling

UR - http://www.scopus.com/inward/record.url?scp=23744438810&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=23744438810&partnerID=8YFLogxK

U2 - 10.1196/annals.1341.008

DO - 10.1196/annals.1341.008

M3 - Article

VL - 1047

SP - 86

EP - 98

JO - Annals of the New York Academy of Sciences

JF - Annals of the New York Academy of Sciences

SN - 0077-8923

ER -