Calcium intake is not related to breast cancer risk among Singapore Chinese women

Jingmei Li, Woon Puay Koh, Ai Zhen Jin, Jian Min Yuan, Mimi C. Yu, Lesley M. Butler

Research output: Contribution to journalArticle

6 Scopus citations

Abstract

There is experimental evidence that calcium protects against breast cancer development. Prospective epidemiologic studies supporting a protective effect of calcium on breast cancer risk have mainly been limited to Western populations. We examined the association between calcium intake and breast cancer risk in the Singapore Chinese Health Study, a large population-based prospective cohort. Calcium intake and supplement use was assessed by in-person interviewer using a validated food frequency questionnaire. After a mean follow-up of 14.2±3.5 years, 823 cohort participants developed invasive breast cancer. Multivariate proportional hazards regression models were fitted to examine the associations between calcium intake and breast cancer risk. Vegetables were the primary food source of calcium in this study population, followed by dairy products, grains and soy foods. Calcium intake was not associated with breast cancer risk, comparing highest quartile (>345.6 mg/1,000 kcal/day) to lowest quartile (<204.5 mg/1,000 kcal/day) of intake. There was no evidence of effect modification by menopausal status, body mass index, dietary vitamin D or stage of disease at diagnosis. Our findings do not support a hypothesis for calcium in breast cancer chemoprevention, contrary to findings from previous studies among Western populations with higher calcium intake primarily from dairy products and supplements. What's new? Studies on Western populations have reported that increased calcium intake can help prevent breast cancer. Asian populations, however, have low incidence of breast cancer, yet consume little calcium. This study investigated whether any link can be observed between calcium intake and breast cancer in Asian populations. The authors found no association between breast cancer risk and calcium, consumed either from food or supplements, in a Singaporean Chinese population. This is in contrast to three previous studies on Asian populations in Japan and China, but this could be attributed to differences in study design; while the others were retrospective studies, the current paper reports the first prospective study to investigate this question.

Original languageEnglish (US)
Pages (from-to)680-686
Number of pages7
JournalInternational Journal of Cancer
Volume133
Issue number3
DOIs
StatePublished - Aug 1 2013
Externally publishedYes

Keywords

  • Asian
  • breast cancer
  • calcium intake
  • Chinese
  • cohort studies

ASJC Scopus subject areas

  • Cancer Research
  • Oncology

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    Li, J., Koh, W. P., Jin, A. Z., Yuan, J. M., Yu, M. C., & Butler, L. M. (2013). Calcium intake is not related to breast cancer risk among Singapore Chinese women. International Journal of Cancer, 133(3), 680-686. https://doi.org/10.1002/ijc.28027