Calcium flux during hemorrhagic shock in baboons

D. Trunkey, James W Holcroft, M. A. Carpenter

Research output: Contribution to journalArticlepeer-review

32 Scopus citations


This study represents the first reported in a series designed to define the role of calcium in the pathophysiology of shock. The authors have demonstrated a decrease in the concentration of extracellular calcium in hemorrhagic shock in baboons. This is aggravated by a calcium free resuscitation. The authors also have demonstrated that there is an increase in extracellular concentration of magnesium during the shock period; however, this is minimized by a calcium free resuscitation after 2 1/2 hours. The authors conclude, at the present time, that calcium should be present in resuscitation fluids and that supplemental calcium should be given when massive transfusions are necessary.

Original languageEnglish (US)
Pages (from-to)633-638
Number of pages6
JournalJournal of Trauma
Issue number8
StatePublished - 1976
Externally publishedYes

ASJC Scopus subject areas

  • Surgery


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