Abstract
Smooth muscle cells are ultimately responsible for determining vascular luminal diameter and blood flow. Dynamic changes in intracellular calcium are a critical mechanism regulating vascular smooth muscle contractility. Processes influencing intracellular calcium are therefore important regulators of vascular function with physiological and pathophysiological consequences. In this review we discuss the major dynamic calcium signals identified and characterized in vascular smooth muscle cells. These signals vary with respect to their mechanisms of generation, temporal properties, and spatial distributions. The calcium signals discussed include calcium waves, junctional calcium transients, calcium sparks, calcium puffs, and L-type calcium channel sparklets. For each calcium signal we address underlying mechanisms, general properties, physiological importance, and regulation.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 281-289 |
| Number of pages | 9 |
| Journal | Microcirculation |
| Volume | 20 |
| Issue number | 4 |
| DOIs | |
| State | Published - May 2013 |
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Keywords
- Calcium sparklets
- Calcium sparks
- Calcium waves
- Junctional calcium transients
ASJC Scopus subject areas
- Physiology
- Physiology (medical)
- Molecular Biology
- Cardiology and Cardiovascular Medicine
Cite this
Calcium Dynamics in Vascular Smooth Muscle. / Amberg, Gregory C.; Navedo, Manuel F.
In: Microcirculation, Vol. 20, No. 4, 05.2013, p. 281-289.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Calcium Dynamics in Vascular Smooth Muscle
AU - Amberg, Gregory C.
AU - Navedo, Manuel F
PY - 2013/5
Y1 - 2013/5
N2 - Smooth muscle cells are ultimately responsible for determining vascular luminal diameter and blood flow. Dynamic changes in intracellular calcium are a critical mechanism regulating vascular smooth muscle contractility. Processes influencing intracellular calcium are therefore important regulators of vascular function with physiological and pathophysiological consequences. In this review we discuss the major dynamic calcium signals identified and characterized in vascular smooth muscle cells. These signals vary with respect to their mechanisms of generation, temporal properties, and spatial distributions. The calcium signals discussed include calcium waves, junctional calcium transients, calcium sparks, calcium puffs, and L-type calcium channel sparklets. For each calcium signal we address underlying mechanisms, general properties, physiological importance, and regulation.
AB - Smooth muscle cells are ultimately responsible for determining vascular luminal diameter and blood flow. Dynamic changes in intracellular calcium are a critical mechanism regulating vascular smooth muscle contractility. Processes influencing intracellular calcium are therefore important regulators of vascular function with physiological and pathophysiological consequences. In this review we discuss the major dynamic calcium signals identified and characterized in vascular smooth muscle cells. These signals vary with respect to their mechanisms of generation, temporal properties, and spatial distributions. The calcium signals discussed include calcium waves, junctional calcium transients, calcium sparks, calcium puffs, and L-type calcium channel sparklets. For each calcium signal we address underlying mechanisms, general properties, physiological importance, and regulation.
KW - Calcium sparklets
KW - Calcium sparks
KW - Calcium waves
KW - Junctional calcium transients
UR - http://www.scopus.com/inward/record.url?scp=84877683260&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84877683260&partnerID=8YFLogxK
U2 - 10.1111/micc.12046
DO - 10.1111/micc.12046
M3 - Article
C2 - 23384444
AN - SCOPUS:84877683260
VL - 20
SP - 281
EP - 289
JO - Microcirculation
JF - Microcirculation
SN - 1073-9688
IS - 4
ER -