Calcium cycling and signaling in cardiac myocytes

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Abstract

Calcium (Ca) is a universal intracellular second messenger. In muscle, Ca is best known for its role in contractile activation. However, in recent years the critical role of Ca in other myocyte processes has become increasingly clear. This review focuses on Ca signaling in cardiac myocytes as pertaining to electrophysiology (including action potentials and arrhythmias), excitation-contraction coupling, modulation of contractile function, energy supply-demand balance (including mitochondrial function), cell death, and transcription regulation. Importantly, although such diverse Ca-dependent regulations occur simultaneously in a cell, the cell can distinguish distinct signals by local Ca or protein complexes and differential Ca signal integration.

Original languageEnglish (US)
Pages (from-to)23-49
Number of pages27
JournalAnnual Review of Physiology
Volume70
DOIs
StatePublished - 2008
Externally publishedYes

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Keywords

  • Ca channels
  • Calmodulin
  • Contraction
  • Mitochondria
  • Sarcoplasmic reticulum

ASJC Scopus subject areas

  • Physiology

Cite this

Calcium cycling and signaling in cardiac myocytes. / Bers, Donald M.

In: Annual Review of Physiology, Vol. 70, 2008, p. 23-49.

Research output: Contribution to journalArticle