Abstract
Differentiated mouse neuroblastoma cells (line C 1300, clone N-18-TG2A1) were investigated by intracellular dialysis. A slow component was found in the potential-dependent inward current of these cells. The results of investigation of changes in amplitude of this component during variation of the ionic composition of the external and internal solutions showed that this component is due to transport of calcium ions. A calcium current was observed in all cells tested. The region of its activation was between -70 and -65 mV; maximal values of this current were reached when the membrane potential was between -30 and -40 mV. The kinetic characteristics of this current were examined. In its kinetics and potential-dependence, this calcium current of the mouse neuroblastoma cell membrane is analogous to the fast component of the calcium current in normal neurons of rat spinal ganglia.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 419-422 |
| Number of pages | 4 |
| Journal | Neurophysiology |
| Volume | 16 |
| Issue number | 4 |
| DOIs | |
| State | Published - Jul 1984 |
| Externally published | Yes |
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ASJC Scopus subject areas
- Neuroscience(all)
- Physiology
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Calcium currents of differentiated mouse neuroblastoma cells. / Veselovskii, N. S.; Pogorelaya, N. Kh; Fomina, Alla F.
In: Neurophysiology, Vol. 16, No. 4, 07.1984, p. 419-422.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Calcium currents of differentiated mouse neuroblastoma cells
AU - Veselovskii, N. S.
AU - Pogorelaya, N. Kh
AU - Fomina, Alla F
PY - 1984/7
Y1 - 1984/7
N2 - Differentiated mouse neuroblastoma cells (line C 1300, clone N-18-TG2A1) were investigated by intracellular dialysis. A slow component was found in the potential-dependent inward current of these cells. The results of investigation of changes in amplitude of this component during variation of the ionic composition of the external and internal solutions showed that this component is due to transport of calcium ions. A calcium current was observed in all cells tested. The region of its activation was between -70 and -65 mV; maximal values of this current were reached when the membrane potential was between -30 and -40 mV. The kinetic characteristics of this current were examined. In its kinetics and potential-dependence, this calcium current of the mouse neuroblastoma cell membrane is analogous to the fast component of the calcium current in normal neurons of rat spinal ganglia.
AB - Differentiated mouse neuroblastoma cells (line C 1300, clone N-18-TG2A1) were investigated by intracellular dialysis. A slow component was found in the potential-dependent inward current of these cells. The results of investigation of changes in amplitude of this component during variation of the ionic composition of the external and internal solutions showed that this component is due to transport of calcium ions. A calcium current was observed in all cells tested. The region of its activation was between -70 and -65 mV; maximal values of this current were reached when the membrane potential was between -30 and -40 mV. The kinetic characteristics of this current were examined. In its kinetics and potential-dependence, this calcium current of the mouse neuroblastoma cell membrane is analogous to the fast component of the calcium current in normal neurons of rat spinal ganglia.
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UR - http://www.scopus.com/inward/citedby.url?scp=34250139661&partnerID=8YFLogxK
U2 - 10.1007/BF01053499
DO - 10.1007/BF01053499
M3 - Article
AN - SCOPUS:34250139661
VL - 16
SP - 419
EP - 422
JO - Neurophysiology
JF - Neurophysiology
SN - 0090-2977
IS - 4
ER -