Calcium currents of differentiated mouse neuroblastoma cells

N. S. Veselovskii, N. Kh Pogorelaya, Alla F Fomina

Research output: Contribution to journalArticle

Abstract

Differentiated mouse neuroblastoma cells (line C 1300, clone N-18-TG2A1) were investigated by intracellular dialysis. A slow component was found in the potential-dependent inward current of these cells. The results of investigation of changes in amplitude of this component during variation of the ionic composition of the external and internal solutions showed that this component is due to transport of calcium ions. A calcium current was observed in all cells tested. The region of its activation was between -70 and -65 mV; maximal values of this current were reached when the membrane potential was between -30 and -40 mV. The kinetic characteristics of this current were examined. In its kinetics and potential-dependence, this calcium current of the mouse neuroblastoma cell membrane is analogous to the fast component of the calcium current in normal neurons of rat spinal ganglia.

Original languageEnglish (US)
Pages (from-to)419-422
Number of pages4
JournalNeurophysiology
Volume16
Issue number4
DOIs
StatePublished - Jul 1984
Externally publishedYes

ASJC Scopus subject areas

  • Neuroscience(all)
  • Physiology

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