Calcium Channels in Vascular Smooth Muscle

D. Ghosh, A. U. Syed, M. P. Prada, M. A. Nystoriak, L. F. Santana, M. Nieves-Cintrón, M. F. Navedo

Research output: Contribution to journalArticle

10 Scopus citations

Abstract

Calcium (Ca2+) plays a central role in excitation, contraction, transcription, and proliferation of vascular smooth muscle cells (VSMs). Precise regulation of intracellular Ca2+ concentration ([Ca2+]i) is crucial for proper physiological VSM function. Studies over the last several decades have revealed that VSMs express a variety of Ca2+-permeable channels that orchestrate a dynamic, yet finely tuned regulation of [Ca2+]i In this review, we discuss the major Ca2+-permeable channels expressed in VSM and their contribution to vascular physiology and pathology.

Original languageEnglish (US)
JournalAdvances in Pharmacology
DOIs
StateAccepted/In press - 2016

Keywords

  • Arteries
  • Ca signaling
  • Contraction
  • Ion channels
  • Myogenic tone
  • Sarcoplasmic reticulum

ASJC Scopus subject areas

  • Pharmacology

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