Calcium Channels in Vascular Smooth Muscle

D. Ghosh, A. U. Syed, M. P. Prada, M. A. Nystoriak, L. F. Santana, M. Nieves-Cintrón, M. F. Navedo

Research output: Contribution to journalArticle

6 Citations (Scopus)

Abstract

Calcium (Ca2+) plays a central role in excitation, contraction, transcription, and proliferation of vascular smooth muscle cells (VSMs). Precise regulation of intracellular Ca2+ concentration ([Ca2+]i) is crucial for proper physiological VSM function. Studies over the last several decades have revealed that VSMs express a variety of Ca2+-permeable channels that orchestrate a dynamic, yet finely tuned regulation of [Ca2+]i In this review, we discuss the major Ca2+-permeable channels expressed in VSM and their contribution to vascular physiology and pathology.

Original languageEnglish (US)
JournalAdvances in Pharmacology
DOIs
StateAccepted/In press - 2016

Fingerprint

Calcium Channels
Vascular Smooth Muscle
Smooth Muscle Myocytes
Blood Vessels
Pathology
Calcium

Keywords

  • Arteries
  • Ca signaling
  • Contraction
  • Ion channels
  • Myogenic tone
  • Sarcoplasmic reticulum

ASJC Scopus subject areas

  • Pharmacology

Cite this

Calcium Channels in Vascular Smooth Muscle. / Ghosh, D.; Syed, A. U.; Prada, M. P.; Nystoriak, M. A.; Santana, L. F.; Nieves-Cintrón, M.; Navedo, M. F.

In: Advances in Pharmacology, 2016.

Research output: Contribution to journalArticle

@article{4d4593269b1c49a0a67717babd1ca693,
title = "Calcium Channels in Vascular Smooth Muscle",
abstract = "Calcium (Ca2+) plays a central role in excitation, contraction, transcription, and proliferation of vascular smooth muscle cells (VSMs). Precise regulation of intracellular Ca2+ concentration ([Ca2+]i) is crucial for proper physiological VSM function. Studies over the last several decades have revealed that VSMs express a variety of Ca2+-permeable channels that orchestrate a dynamic, yet finely tuned regulation of [Ca2+]i In this review, we discuss the major Ca2+-permeable channels expressed in VSM and their contribution to vascular physiology and pathology.",
keywords = "Arteries, Ca signaling, Contraction, Ion channels, Myogenic tone, Sarcoplasmic reticulum",
author = "D. Ghosh and Syed, {A. U.} and Prada, {M. P.} and Nystoriak, {M. A.} and Santana, {L. F.} and M. Nieves-Cintr{\'o}n and Navedo, {M. F.}",
year = "2016",
doi = "10.1016/bs.apha.2016.08.002",
language = "English (US)",
journal = "Advances in pharmacology (San Diego, Calif.)",
issn = "1054-3589",
publisher = "Academic Press Inc.",

}

TY - JOUR

T1 - Calcium Channels in Vascular Smooth Muscle

AU - Ghosh, D.

AU - Syed, A. U.

AU - Prada, M. P.

AU - Nystoriak, M. A.

AU - Santana, L. F.

AU - Nieves-Cintrón, M.

AU - Navedo, M. F.

PY - 2016

Y1 - 2016

N2 - Calcium (Ca2+) plays a central role in excitation, contraction, transcription, and proliferation of vascular smooth muscle cells (VSMs). Precise regulation of intracellular Ca2+ concentration ([Ca2+]i) is crucial for proper physiological VSM function. Studies over the last several decades have revealed that VSMs express a variety of Ca2+-permeable channels that orchestrate a dynamic, yet finely tuned regulation of [Ca2+]i In this review, we discuss the major Ca2+-permeable channels expressed in VSM and their contribution to vascular physiology and pathology.

AB - Calcium (Ca2+) plays a central role in excitation, contraction, transcription, and proliferation of vascular smooth muscle cells (VSMs). Precise regulation of intracellular Ca2+ concentration ([Ca2+]i) is crucial for proper physiological VSM function. Studies over the last several decades have revealed that VSMs express a variety of Ca2+-permeable channels that orchestrate a dynamic, yet finely tuned regulation of [Ca2+]i In this review, we discuss the major Ca2+-permeable channels expressed in VSM and their contribution to vascular physiology and pathology.

KW - Arteries

KW - Ca signaling

KW - Contraction

KW - Ion channels

KW - Myogenic tone

KW - Sarcoplasmic reticulum

UR - http://www.scopus.com/inward/record.url?scp=84991200181&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84991200181&partnerID=8YFLogxK

U2 - 10.1016/bs.apha.2016.08.002

DO - 10.1016/bs.apha.2016.08.002

M3 - Article

C2 - 28212803

AN - SCOPUS:84991200181

JO - Advances in pharmacology (San Diego, Calif.)

JF - Advances in pharmacology (San Diego, Calif.)

SN - 1054-3589

ER -