Calcium and cardiomyopathies.

E. G. Kranias, Donald M Bers

Research output: Contribution to journalArticle

70 Citations (Scopus)

Abstract

Regulation of Calcium (Ca) cycling by the sarcoplasmic reticulum (SR) underlies the control of cardiac contraction during excitation-contraction (E-C) coupling. Moreover, alterations in E-C coupling occurring in cardiac hypertrophy and heart failure are characterized by abnormal Ca-cycling through the SR network. A large body of evidence points to the central role of: a) SERCA and its regulator phospholamban (PLN) in the modulation of cardiac relaxation; b) calsequestrin in the regulation of SR Ca-load; and c) the ryanodine receptor (RyR) Ca-channel in the control of SR Ca-release. The levels or activity of these key Ca-handling proteins are altered in cardiomyopathies, and these changes have been linked to the deteriorated cardiac function and remodeling. Furthermore, genetic variants in these SR Ca-cycling proteins have been identified, which may predispose to heart failure or fatal arrhythmias. This chapter concentrates on the pivotal role of SR Ca-cycling proteins in health and disease with specific emphasis on their recently reported genetic modifiers.

Original languageEnglish (US)
Pages (from-to)523-537
Number of pages15
JournalSub-Cellular Biochemistry
Volume45
StatePublished - 2007
Externally publishedYes

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Cardiomyopathies
Sarcoplasmic Reticulum
Calcium
Excitation Contraction Coupling
Heart Failure
Calsequestrin
Ryanodine Receptor Calcium Release Channel
Proteins
Cardiomegaly
Calcium Channels
Cardiac Arrhythmias
Modulation
Health

ASJC Scopus subject areas

  • Medicine(all)

Cite this

Calcium and cardiomyopathies. / Kranias, E. G.; Bers, Donald M.

In: Sub-Cellular Biochemistry, Vol. 45, 2007, p. 523-537.

Research output: Contribution to journalArticle

Kranias, EG & Bers, DM 2007, 'Calcium and cardiomyopathies.', Sub-Cellular Biochemistry, vol. 45, pp. 523-537.
Kranias, E. G. ; Bers, Donald M. / Calcium and cardiomyopathies. In: Sub-Cellular Biochemistry. 2007 ; Vol. 45. pp. 523-537.
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