Calcitonin gene-related peptide mediates the gastric hyperemic response to acid back-diffusion

Dong Sheng Li, Helen E Raybould, E. Quintero, Paul H. Guth

Research output: Contribution to journalArticle

85 Scopus citations

Abstract

Disruption of the gastric mucosal barrier with resultant increased acid back-diffusion leads to a marked increase in gastric mucosal blood flow (GMBF). This increase in GMBF is blocked by ablation of capsaicin-sensitive sensory neurons. The gastric arterioles are densely innervated by afferent neurons containing vasodilator peptides, calcitonin gene-related peptide (CGRP) being the most potent of these. We investigated (a) whether CGRP is the vasodilator mediator released by acid stimulation of capsaicin-sensitive sensory neurons and (b) whether the resultant hyperemia protects against the acid-induced mucosal injury. When the stomach was perfused with 0.15N HCl plus 15% ethanol, GMBF significantly increased by 70%. This hyperemic response was completely blocked by intra-arterial infusion of human CGRP8-37 (500 pmol/min), a CGRP-receptor antagonist, close to the stomach. With the blockade of the hyperemic response to acid back-diffusion, gross and histological mucosal damage were significantly aggravated. It is concluded that CGRP mediates the gastric hyperemic response to acid back-diffusion and that this gastric hyperemic response is an important protective factor against acid-induced injury.

Original languageEnglish (US)
Pages (from-to)1124-1128
Number of pages5
JournalGastroenterology
Volume102
Issue number4 PART 1
StatePublished - 1992

ASJC Scopus subject areas

  • Gastroenterology

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