Calbindin immunoreactivity alternates with cytochrome c-oxidase-rich zones in some layers of the primate visual cortex

Marco R. Celio, L. Schärer, John Morrison, A. W. Norman, F. E. Bloom

Research output: Contribution to journalArticle

99 Citations (Scopus)

Abstract

Calcium ions have a pivotal role in many neuronal activities1, but little is known about their involvement in the cortical processing of visual information2. Using immunohistochemical methods, we have now detected a calcium-binding protein, calbindin-D-28K (ref. 3, calbindin), which may confer on certain compartments of cortical area 17 the ability to modulate Ca2+ metabolism. Thus, calbindin occurs in the primate striate cortex in a pattern almost complementary to that displaying strong cytochrome c-oxidase activity. From this and other observations, we deduce that the distribution of calbindin-immunoreactive sites corresponds mainly to extra-geniculocortical connections of the primary visual cortex. This implies that the geniculocortical and extra-geniculocortical compartments of area 17 differ in an intracellular system for Ca2+ homeostasis.

Original languageEnglish (US)
Pages (from-to)715-717
Number of pages3
JournalNature
Volume323
Issue number6090
DOIs
StatePublished - Dec 1 1986
Externally publishedYes

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Calbindins
Electron Transport Complex IV
Visual Cortex
Primates
S100 Calcium Binding Protein G
Calcium-Binding Proteins
Homeostasis
Ions
Calcium

ASJC Scopus subject areas

  • General

Cite this

Calbindin immunoreactivity alternates with cytochrome c-oxidase-rich zones in some layers of the primate visual cortex. / Celio, Marco R.; Schärer, L.; Morrison, John; Norman, A. W.; Bloom, F. E.

In: Nature, Vol. 323, No. 6090, 01.12.1986, p. 715-717.

Research output: Contribution to journalArticle

Celio, Marco R. ; Schärer, L. ; Morrison, John ; Norman, A. W. ; Bloom, F. E. / Calbindin immunoreactivity alternates with cytochrome c-oxidase-rich zones in some layers of the primate visual cortex. In: Nature. 1986 ; Vol. 323, No. 6090. pp. 715-717.
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