Abstract
There are Ca channels in the plasma membrane and also the sarcoplasmic reticulum (SR) membrane in cardiac myocytes. The relationship between channel structure, associated proteins and function of these Ca channels is discussed. The sarcolemmal Ca channels are crucial both to the basic cellular electrophysiological properties and control of cardiac contractility (via excitation-contraction coupling). The intracellular Ca release channels (or ryanodine receptors) respond to triggering events mediated by sarcolemmal ion currents and are largely responsible for releasing Ca which activates the myofilaments to produce contraction. Several possible mechanisms of excitation-contraction coupling are discussed. The Ca released from the SR can also feedback on several sarcolemmal ion currents and alter action potential configuration as well as contribute to arrhythmogenesis.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 339-360 |
| Number of pages | 22 |
| Journal | Cardiovascular Research |
| Volume | 42 |
| Issue number | 2 |
| DOIs | |
| State | Published - May 1999 |
| Externally published | Yes |
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ASJC Scopus subject areas
- Cardiology and Cardiovascular Medicine
Cite this
Ca channels in cardiac myocytes : Structure and function in Ca influx and intracellular Ca release. / Bers, Donald M; Perez-Reyes, Edward.
In: Cardiovascular Research, Vol. 42, No. 2, 05.1999, p. 339-360.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Ca channels in cardiac myocytes
T2 - Structure and function in Ca influx and intracellular Ca release
AU - Bers, Donald M
AU - Perez-Reyes, Edward
PY - 1999/5
Y1 - 1999/5
N2 - There are Ca channels in the plasma membrane and also the sarcoplasmic reticulum (SR) membrane in cardiac myocytes. The relationship between channel structure, associated proteins and function of these Ca channels is discussed. The sarcolemmal Ca channels are crucial both to the basic cellular electrophysiological properties and control of cardiac contractility (via excitation-contraction coupling). The intracellular Ca release channels (or ryanodine receptors) respond to triggering events mediated by sarcolemmal ion currents and are largely responsible for releasing Ca which activates the myofilaments to produce contraction. Several possible mechanisms of excitation-contraction coupling are discussed. The Ca released from the SR can also feedback on several sarcolemmal ion currents and alter action potential configuration as well as contribute to arrhythmogenesis.
AB - There are Ca channels in the plasma membrane and also the sarcoplasmic reticulum (SR) membrane in cardiac myocytes. The relationship between channel structure, associated proteins and function of these Ca channels is discussed. The sarcolemmal Ca channels are crucial both to the basic cellular electrophysiological properties and control of cardiac contractility (via excitation-contraction coupling). The intracellular Ca release channels (or ryanodine receptors) respond to triggering events mediated by sarcolemmal ion currents and are largely responsible for releasing Ca which activates the myofilaments to produce contraction. Several possible mechanisms of excitation-contraction coupling are discussed. The Ca released from the SR can also feedback on several sarcolemmal ion currents and alter action potential configuration as well as contribute to arrhythmogenesis.
UR - http://www.scopus.com/inward/record.url?scp=0033017488&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0033017488&partnerID=8YFLogxK
U2 - 10.1016/S0008-6363(99)00038-3
DO - 10.1016/S0008-6363(99)00038-3
M3 - Article
C2 - 10533572
AN - SCOPUS:0033017488
VL - 42
SP - 339
EP - 360
JO - Cardiovascular Research
JF - Cardiovascular Research
SN - 0008-6363
IS - 2
ER -