C1-BYPASS COMPLEMENT-ACTIVATION PATHWAY IN PATIENTS WITH CHRONIC URTICARIA AND ANGIO-ŒDEMA

Mark Ballow, GeorgeW Ward, M. Eric Gershwin, NoorbibiK Day

Research output: Contribution to journalArticle

28 Scopus citations

Abstract

During the routine screening of 152 patients with urticaria or angio-œdema for hypocomplementæmia, 4 patients were found to have low serum levels of the third component of complement (C). These patients were noteworthy and differed from previous reports of patients with urticaria-like skin lesions and hypocomplementæmia because of the absence of immune-complex disease. In addition to the low C3, 2 of these patients were unique on the basis of low serum levels of hæmolytic Cl, Clq, Cls, and properdin factor B, but normal concentrations of C4 and C2. These C abnormalities may reflect a new clinical entity, and these cases form the first description in man of the C1-bypass complement-activation pathway.

Original languageEnglish (US)
Pages (from-to)248-250
Number of pages3
JournalThe Lancet
Volume306
Issue number7928
DOIs
StatePublished - Aug 9 1975

ASJC Scopus subject areas

  • Medicine(all)

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