C-terminal tensin-like (CTEN)

A promising biomarker and target for cancer

Research output: Contribution to journalArticle

12 Citations (Scopus)

Abstract

C-terminal tensin-like (cten, also known as tensin4, TNS4) is a member of the tensin family. Cten protein, like the other three tensin family members, localizes to focal adhesion sites but only shares sequence homology with other tensins at its C-terminal region, which contains the SH2 and PTB domains. Cten is abundantly expressed in normal prostate and placenta and is down-regulated in prostate cancer. However, overexpression of cten frequently associates with tumors derived from breast, colon, lung, stomach, skin and pancreas. A variety of cancer-associated growth factors and cytokines induce cten expression. Up-regulated cten promotes cell motility, prolongs epidermal growth factor receptor signaling, and enhances tumorigenicity. Emerging findings suggest that cten is a promising biomarker and therapeutic target for various cancers.

Original languageEnglish (US)
Pages (from-to)150-154
Number of pages5
JournalInternational Journal of Biochemistry and Cell Biology
Volume51
Issue number1
DOIs
StatePublished - 2014

Fingerprint

Biomarkers
Tumor Biomarkers
Epidermal Growth Factor Receptor
Tumors
Intercellular Signaling Peptides and Proteins
Skin
Adhesion
Cytokines
Proteins
Focal Adhesions
src Homology Domains
Sequence Homology
Placenta
Cell Movement
Prostate
Pancreas
Prostatic Neoplasms
Stomach
Colon
Breast Neoplasms

Keywords

  • Cten
  • Focal adhesion
  • Tensin
  • Tumor promoter
  • Tumor suppressor

ASJC Scopus subject areas

  • Biochemistry
  • Cell Biology

Cite this

C-terminal tensin-like (CTEN) : A promising biomarker and target for cancer. / Lo, Su Hao.

In: International Journal of Biochemistry and Cell Biology, Vol. 51, No. 1, 2014, p. 150-154.

Research output: Contribution to journalArticle

@article{5794bb703819405482c1ce52aeef5721,
title = "C-terminal tensin-like (CTEN): A promising biomarker and target for cancer",
abstract = "C-terminal tensin-like (cten, also known as tensin4, TNS4) is a member of the tensin family. Cten protein, like the other three tensin family members, localizes to focal adhesion sites but only shares sequence homology with other tensins at its C-terminal region, which contains the SH2 and PTB domains. Cten is abundantly expressed in normal prostate and placenta and is down-regulated in prostate cancer. However, overexpression of cten frequently associates with tumors derived from breast, colon, lung, stomach, skin and pancreas. A variety of cancer-associated growth factors and cytokines induce cten expression. Up-regulated cten promotes cell motility, prolongs epidermal growth factor receptor signaling, and enhances tumorigenicity. Emerging findings suggest that cten is a promising biomarker and therapeutic target for various cancers.",
keywords = "Cten, Focal adhesion, Tensin, Tumor promoter, Tumor suppressor",
author = "Lo, {Su Hao}",
year = "2014",
doi = "10.1016/j.biocel.2014.04.003",
language = "English (US)",
volume = "51",
pages = "150--154",
journal = "International Journal of Biochemistry and Cell Biology",
issn = "1357-2725",
publisher = "Elsevier Limited",
number = "1",

}

TY - JOUR

T1 - C-terminal tensin-like (CTEN)

T2 - A promising biomarker and target for cancer

AU - Lo, Su Hao

PY - 2014

Y1 - 2014

N2 - C-terminal tensin-like (cten, also known as tensin4, TNS4) is a member of the tensin family. Cten protein, like the other three tensin family members, localizes to focal adhesion sites but only shares sequence homology with other tensins at its C-terminal region, which contains the SH2 and PTB domains. Cten is abundantly expressed in normal prostate and placenta and is down-regulated in prostate cancer. However, overexpression of cten frequently associates with tumors derived from breast, colon, lung, stomach, skin and pancreas. A variety of cancer-associated growth factors and cytokines induce cten expression. Up-regulated cten promotes cell motility, prolongs epidermal growth factor receptor signaling, and enhances tumorigenicity. Emerging findings suggest that cten is a promising biomarker and therapeutic target for various cancers.

AB - C-terminal tensin-like (cten, also known as tensin4, TNS4) is a member of the tensin family. Cten protein, like the other three tensin family members, localizes to focal adhesion sites but only shares sequence homology with other tensins at its C-terminal region, which contains the SH2 and PTB domains. Cten is abundantly expressed in normal prostate and placenta and is down-regulated in prostate cancer. However, overexpression of cten frequently associates with tumors derived from breast, colon, lung, stomach, skin and pancreas. A variety of cancer-associated growth factors and cytokines induce cten expression. Up-regulated cten promotes cell motility, prolongs epidermal growth factor receptor signaling, and enhances tumorigenicity. Emerging findings suggest that cten is a promising biomarker and therapeutic target for various cancers.

KW - Cten

KW - Focal adhesion

KW - Tensin

KW - Tumor promoter

KW - Tumor suppressor

UR - http://www.scopus.com/inward/record.url?scp=84899811577&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84899811577&partnerID=8YFLogxK

U2 - 10.1016/j.biocel.2014.04.003

DO - 10.1016/j.biocel.2014.04.003

M3 - Article

VL - 51

SP - 150

EP - 154

JO - International Journal of Biochemistry and Cell Biology

JF - International Journal of Biochemistry and Cell Biology

SN - 1357-2725

IS - 1

ER -