Abstract
Recent research suggests a central role for inflammatory mechanisms in cognitive decline that may occur prior to evidence of neurodegeneration. Limited information exists, however, regarding the relationship between low-grade inflammation and cognitive function in healthy older adults. This study examined the relation between inflammation, verbal memory consolidation, and medial temporal lobe volumes in a cohort of older community-dwelling subjects. Subjects included 141 functionally intact, community-dwelling older adults with detectable (n= 76) and undetectable (n= 65) levels of C-reactive protein. A verbal episodic memory measure was administered to all subjects, and measures of delayed recall and recognition memory were assessed. A semiautomated parcellation program was used to analyze structural MRI scans. On the episodic memory task, analysis of covariance revealed a significant CRP group by memory recall interaction, such that participants with detectable levels of CRP evidenced worse performance after a delay compared to those with undetectable levels of CRP. Individuals with detectable CRP also demonstrated lower performance on a measure of recognition memory. Imaging data demonstrated smaller left medial temporal lobe volumes in the detectable CRP group as compared with the undetectable CRP group. These findings underscore a potential role for inflammation in cognitive aging as a modifiable risk factor.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 103-108 |
| Number of pages | 6 |
| Journal | Brain, Behavior, and Immunity |
| Volume | 26 |
| Issue number | 1 |
| DOIs | |
| State | Published - Jan 2012 |
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Keywords
- Aging
- C-reactive protein
- Cognition
- Cytokines
- Inflammation
- Memory
- Temporal lobe
ASJC Scopus subject areas
- Immunology
- Behavioral Neuroscience
- Endocrine and Autonomic Systems
Cite this
C-reactive protein is related to memory and medial temporal brain volume in older adults. / Bettcher, Brianne Magouirk; Wilheim, Reva; Rigby, Taylor; Green, Ralph; Miller, Joshua W.; Racine, Caroline A.; Yaffe, Kristine; Miller, Bruce L.; Kramer, Joel H.
In: Brain, Behavior, and Immunity, Vol. 26, No. 1, 01.2012, p. 103-108.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - C-reactive protein is related to memory and medial temporal brain volume in older adults
AU - Bettcher, Brianne Magouirk
AU - Wilheim, Reva
AU - Rigby, Taylor
AU - Green, Ralph
AU - Miller, Joshua W.
AU - Racine, Caroline A.
AU - Yaffe, Kristine
AU - Miller, Bruce L.
AU - Kramer, Joel H.
PY - 2012/1
Y1 - 2012/1
N2 - Recent research suggests a central role for inflammatory mechanisms in cognitive decline that may occur prior to evidence of neurodegeneration. Limited information exists, however, regarding the relationship between low-grade inflammation and cognitive function in healthy older adults. This study examined the relation between inflammation, verbal memory consolidation, and medial temporal lobe volumes in a cohort of older community-dwelling subjects. Subjects included 141 functionally intact, community-dwelling older adults with detectable (n= 76) and undetectable (n= 65) levels of C-reactive protein. A verbal episodic memory measure was administered to all subjects, and measures of delayed recall and recognition memory were assessed. A semiautomated parcellation program was used to analyze structural MRI scans. On the episodic memory task, analysis of covariance revealed a significant CRP group by memory recall interaction, such that participants with detectable levels of CRP evidenced worse performance after a delay compared to those with undetectable levels of CRP. Individuals with detectable CRP also demonstrated lower performance on a measure of recognition memory. Imaging data demonstrated smaller left medial temporal lobe volumes in the detectable CRP group as compared with the undetectable CRP group. These findings underscore a potential role for inflammation in cognitive aging as a modifiable risk factor.
AB - Recent research suggests a central role for inflammatory mechanisms in cognitive decline that may occur prior to evidence of neurodegeneration. Limited information exists, however, regarding the relationship between low-grade inflammation and cognitive function in healthy older adults. This study examined the relation between inflammation, verbal memory consolidation, and medial temporal lobe volumes in a cohort of older community-dwelling subjects. Subjects included 141 functionally intact, community-dwelling older adults with detectable (n= 76) and undetectable (n= 65) levels of C-reactive protein. A verbal episodic memory measure was administered to all subjects, and measures of delayed recall and recognition memory were assessed. A semiautomated parcellation program was used to analyze structural MRI scans. On the episodic memory task, analysis of covariance revealed a significant CRP group by memory recall interaction, such that participants with detectable levels of CRP evidenced worse performance after a delay compared to those with undetectable levels of CRP. Individuals with detectable CRP also demonstrated lower performance on a measure of recognition memory. Imaging data demonstrated smaller left medial temporal lobe volumes in the detectable CRP group as compared with the undetectable CRP group. These findings underscore a potential role for inflammation in cognitive aging as a modifiable risk factor.
KW - Aging
KW - C-reactive protein
KW - Cognition
KW - Cytokines
KW - Inflammation
KW - Memory
KW - Temporal lobe
UR - http://www.scopus.com/inward/record.url?scp=84860389076&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84860389076&partnerID=8YFLogxK
U2 - 10.1016/j.bbi.2011.07.240
DO - 10.1016/j.bbi.2011.07.240
M3 - Article
C2 - 21843630
AN - SCOPUS:84860389076
VL - 26
SP - 103
EP - 108
JO - Brain, Behavior, and Immunity
JF - Brain, Behavior, and Immunity
SN - 0889-1591
IS - 1
ER -