C-fos protein expression in the nucleus of the solitary tract correlates with cholecystokinin dose injected and food intake in rats

Tilman T. Zittel, Jörg Glatzle, Martin E. Kreis, M. Starlinger, M. Eichner, Helen E Raybould, Horst D. Becker, Ekkehard C. Jehle

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Abstract

C-fos protein expression was investigated in the nucleus of the solitary tract (NTS) in response to increasing cholecystokinin (CCK) doses and food intake in rats by counting the number of c-fos protein positive cells in the NTS. C-fos protein expression in the NTS dose-dependently increased in response to CCK, the lowest effective dose being 0.1 μg/kg. The ED50 for c-fos protein expression in the NTS in response to CCK was calculated to be 0.5 to 1.8 μg/kg, depending on the anatomical level of the NTS investigated. Food intake increased c-fos protein expression in the NTS, the maximum number of c-fos protein positive cells being reached at 90 min after the start of food intake. Regression analysis identified a positive correlation between c-fos protein expression and the amount of food intake. Our data indicate that subpopulations of the NTS that are activated by CCK or food intake are involved into the short-term regulation of food intake and the neural control of feeding by the caudal brainstem. Copyright (C) 1999 Elsevier Science B.V.

Original languageEnglish (US)
Pages (from-to)1-11
Number of pages11
JournalBrain Research
Volume846
Issue number1
DOIs
StatePublished - Oct 30 1999

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Proto-Oncogene Proteins c-fos
Solitary Nucleus
Cholecystokinin
Protein C
Eating
Appetite Regulation
Brain Stem
Regression Analysis

Keywords

  • Brain-gut axis
  • C-fos protein
  • Cholecystokinin
  • Regulation of food intake
  • Satiety

ASJC Scopus subject areas

  • Neuroscience(all)

Cite this

C-fos protein expression in the nucleus of the solitary tract correlates with cholecystokinin dose injected and food intake in rats. / Zittel, Tilman T.; Glatzle, Jörg; Kreis, Martin E.; Starlinger, M.; Eichner, M.; Raybould, Helen E; Becker, Horst D.; Jehle, Ekkehard C.

In: Brain Research, Vol. 846, No. 1, 30.10.1999, p. 1-11.

Research output: Contribution to journalArticle

Zittel, Tilman T. ; Glatzle, Jörg ; Kreis, Martin E. ; Starlinger, M. ; Eichner, M. ; Raybould, Helen E ; Becker, Horst D. ; Jehle, Ekkehard C. / C-fos protein expression in the nucleus of the solitary tract correlates with cholecystokinin dose injected and food intake in rats. In: Brain Research. 1999 ; Vol. 846, No. 1. pp. 1-11.
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