c-erbB activation in ALV-induced erythroblastosis: novel RNA processing and promoter insertion result in expression of an amino-truncated EGF receptor

Timothy W. Nilsen, Patricia A. Maroney, Raymond G. Goodwin, Fritz M. Rottman, Lyman B. Crittenden, Maribeth A. Raines, Hsing-Jien Kung

Research output: Contribution to journalArticle

105 Citations (Scopus)

Abstract

ALV induced erythroblastosis results from the specific interruption of the host oncogene, c-erbB, by the insertion of an intact provirus. Integrated proviruses are oriented in the same transcriptional direction as c-erbB, and expression of truncated c-erbB transcripts is observed. Evidence, including sequence analysis of cDNA clones, indicates that transcription of truncated c-erbB mRNA is initiated in the 5′ LTR of the integrated provirus. This transcript is processed through a series of remarkable splicing reactions to yield viral gag and env sequences fused to erbB sequences. These results establish a novel pathway of promoter insertion oncogenesis that stands in contrast to the pathways used in the activation of c-myc in B lymphomas.

Original languageEnglish (US)
Pages (from-to)719-726
Number of pages8
JournalCell
Volume41
Issue number3
DOIs
StatePublished - 1985
Externally publishedYes

Fingerprint

Proviruses
Epidermal Growth Factor Receptor
Chemical activation
RNA
Processing
Transcription
Oncogenes
Sequence Analysis
Lymphoma
Carcinogenesis
Complementary DNA
Clone Cells
Messenger RNA

ASJC Scopus subject areas

  • Cell Biology
  • Molecular Biology
  • Medicine(all)

Cite this

c-erbB activation in ALV-induced erythroblastosis : novel RNA processing and promoter insertion result in expression of an amino-truncated EGF receptor. / Nilsen, Timothy W.; Maroney, Patricia A.; Goodwin, Raymond G.; Rottman, Fritz M.; Crittenden, Lyman B.; Raines, Maribeth A.; Kung, Hsing-Jien.

In: Cell, Vol. 41, No. 3, 1985, p. 719-726.

Research output: Contribution to journalArticle

Nilsen, Timothy W. ; Maroney, Patricia A. ; Goodwin, Raymond G. ; Rottman, Fritz M. ; Crittenden, Lyman B. ; Raines, Maribeth A. ; Kung, Hsing-Jien. / c-erbB activation in ALV-induced erythroblastosis : novel RNA processing and promoter insertion result in expression of an amino-truncated EGF receptor. In: Cell. 1985 ; Vol. 41, No. 3. pp. 719-726.
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AU - Raines, Maribeth A.

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