Buspirone attenuates learned helplessness behavior in rats

R. C. Drugan; Jacqueline Crawley; S. M. Paul; P. Skolnick

Buspirone attenuates learned helplessness behavior in rats

R. C. Drugan, Jacqueline Crawley, S. M. Paul, P. Skolnick

Research output: Contribution to journal › Article › peer-review

Abstract

Rats pretreated with either chlordiazepoxide (5 mg/kg) or buspirone (5 mg/kg) did not develop the shuttlebox escape deficit typically observed 24 hours after a session of inescapable tailshock. In contrast, the buspirone analog gepirone (MJ 13805)(2 or 5 mg/kg) did not block this shock-induced learning deficit. These results demonstrate that the nonbenzodiazepine anxiolytic buspirone, like chlordiazepoxide, attenuates the learned helplessness syndrome.

Original language	English (US)
Pages (from-to)	63-67
Number of pages	5
Journal	Drug Development Research
Volume	10
Issue number	2
State	Published - 1987
Externally published	Yes

ASJC Scopus subject areas

Organic Chemistry
Drug Discovery
Pharmacology

Fingerprint Dive into the research topics of 'Buspirone attenuates learned helplessness behavior in rats'. Together they form a unique fingerprint.

Cite this

@article{1342e31456da4d9297535f59109378e2,

title = "Buspirone attenuates learned helplessness behavior in rats",

abstract = "Rats pretreated with either chlordiazepoxide (5 mg/kg) or buspirone (5 mg/kg) did not develop the shuttlebox escape deficit typically observed 24 hours after a session of inescapable tailshock. In contrast, the buspirone analog gepirone (MJ 13805)(2 or 5 mg/kg) did not block this shock-induced learning deficit. These results demonstrate that the nonbenzodiazepine anxiolytic buspirone, like chlordiazepoxide, attenuates the learned helplessness syndrome.",

author = "Drugan, {R. C.} and Jacqueline Crawley and Paul, {S. M.} and P. Skolnick",

year = "1987",

language = "English (US)",

volume = "10",

pages = "63--67",

journal = "Drug Development Research",

issn = "0272-4391",

publisher = "John Wiley and Sons Inc.",

number = "2",

}

TY - JOUR

T1 - Buspirone attenuates learned helplessness behavior in rats

AU - Drugan, R. C.

AU - Crawley, Jacqueline

AU - Paul, S. M.

AU - Skolnick, P.

PY - 1987

Y1 - 1987

N2 - Rats pretreated with either chlordiazepoxide (5 mg/kg) or buspirone (5 mg/kg) did not develop the shuttlebox escape deficit typically observed 24 hours after a session of inescapable tailshock. In contrast, the buspirone analog gepirone (MJ 13805)(2 or 5 mg/kg) did not block this shock-induced learning deficit. These results demonstrate that the nonbenzodiazepine anxiolytic buspirone, like chlordiazepoxide, attenuates the learned helplessness syndrome.

AB - Rats pretreated with either chlordiazepoxide (5 mg/kg) or buspirone (5 mg/kg) did not develop the shuttlebox escape deficit typically observed 24 hours after a session of inescapable tailshock. In contrast, the buspirone analog gepirone (MJ 13805)(2 or 5 mg/kg) did not block this shock-induced learning deficit. These results demonstrate that the nonbenzodiazepine anxiolytic buspirone, like chlordiazepoxide, attenuates the learned helplessness syndrome.

UR - http://www.scopus.com/inward/record.url?scp=0023198196&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0023198196&partnerID=8YFLogxK

M3 - Article

AN - SCOPUS:0023198196

VL - 10

SP - 63

EP - 67

JO - Drug Development Research

JF - Drug Development Research

SN - 0272-4391

IS - 2

ER -