Abstract
Rats pretreated with either chlordiazepoxide (5 mg/kg) or buspirone (5 mg/kg) did not develop the shuttlebox escape deficit typically observed 24 hours after a session of inescapable tailshock. In contrast, the buspirone analog gepirone (MJ 13805)(2 or 5 mg/kg) did not block this shock-induced learning deficit. These results demonstrate that the nonbenzodiazepine anxiolytic buspirone, like chlordiazepoxide, attenuates the learned helplessness syndrome.
Original language | English (US) |
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Pages (from-to) | 63-67 |
Number of pages | 5 |
Journal | Drug Development Research |
Volume | 10 |
Issue number | 2 |
State | Published - 1987 |
Externally published | Yes |
ASJC Scopus subject areas
- Organic Chemistry
- Drug Discovery
- Pharmacology