Buspirone attenuates learned helplessness behavior in rats

R. C. Drugan; Jacqueline Crawley; S. M. Paul; P. Skolnick

Buspirone attenuates learned helplessness behavior in rats

R. C. Drugan, Jacqueline Crawley, S. M. Paul, P. Skolnick

Research output: Contribution to journal › Article

Abstract

Rats pretreated with either chlordiazepoxide (5 mg/kg) or buspirone (5 mg/kg) did not develop the shuttlebox escape deficit typically observed 24 hours after a session of inescapable tailshock. In contrast, the buspirone analog gepirone (MJ 13805)(2 or 5 mg/kg) did not block this shock-induced learning deficit. These results demonstrate that the nonbenzodiazepine anxiolytic buspirone, like chlordiazepoxide, attenuates the learned helplessness syndrome.

Original language	English (US)
Pages (from-to)	63-67
Number of pages	5
Journal	Drug Development Research
Volume	10
Issue number	2
State	Published - 1987
Externally published	Yes

ASJC Scopus subject areas

Organic Chemistry
Drug Discovery
Pharmacology

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Drugan, R. C., Crawley, J., Paul, S. M., & Skolnick, P. (1987). Buspirone attenuates learned helplessness behavior in rats. Drug Development Research, 10(2), 63-67.

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N2 - Rats pretreated with either chlordiazepoxide (5 mg/kg) or buspirone (5 mg/kg) did not develop the shuttlebox escape deficit typically observed 24 hours after a session of inescapable tailshock. In contrast, the buspirone analog gepirone (MJ 13805)(2 or 5 mg/kg) did not block this shock-induced learning deficit. These results demonstrate that the nonbenzodiazepine anxiolytic buspirone, like chlordiazepoxide, attenuates the learned helplessness syndrome.

AB - Rats pretreated with either chlordiazepoxide (5 mg/kg) or buspirone (5 mg/kg) did not develop the shuttlebox escape deficit typically observed 24 hours after a session of inescapable tailshock. In contrast, the buspirone analog gepirone (MJ 13805)(2 or 5 mg/kg) did not block this shock-induced learning deficit. These results demonstrate that the nonbenzodiazepine anxiolytic buspirone, like chlordiazepoxide, attenuates the learned helplessness syndrome.

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