Buspirone attenuates learned helplessness behavior in rats

R. C. Drugan, Jacqueline Crawley, S. M. Paul, P. Skolnick

Research output: Contribution to journalArticlepeer-review

26 Scopus citations


Rats pretreated with either chlordiazepoxide (5 mg/kg) or buspirone (5 mg/kg) did not develop the shuttlebox escape deficit typically observed 24 hours after a session of inescapable tailshock. In contrast, the buspirone analog gepirone (MJ 13805)(2 or 5 mg/kg) did not block this shock-induced learning deficit. These results demonstrate that the nonbenzodiazepine anxiolytic buspirone, like chlordiazepoxide, attenuates the learned helplessness syndrome.

Original languageEnglish (US)
Pages (from-to)63-67
Number of pages5
JournalDrug Development Research
Issue number2
StatePublished - 1987
Externally publishedYes

ASJC Scopus subject areas

  • Organic Chemistry
  • Drug Discovery
  • Pharmacology


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