TY - JOUR
T1 - Burn-Induced Coagulopathies
T2 - a Comprehensive Review
AU - Ball, Robert L.
AU - Keyloun, John W.
AU - Brummel-Ziedins, Kathleen
AU - Orfeo, Thomas
AU - Palmieri, Tina L.
AU - Johnson, Laura S.
AU - Moffatt, Lauren T.
AU - Pusateri, Anthony E.
AU - Shupp, Jeffrey W.
PY - 2020/8/1
Y1 - 2020/8/1
N2 - Burn-induced coagulopathy is not well understood, and consensus on diagnosis, prevention, and treatments are lacking. In this review, literature on burn-induced (and associated) coagulopathy is presented along with the current understanding of the effects of burn injury on the interactions among coagulation, fibrinolysis, and inflammation in the acute resuscitative phase and reconstructive phase of care. The role of conventional tests of coagulopathy and functional assays like thromboelastography or thromboelastometry will also be discussed. Finally, reported methods for the prevention and treatment of complications related to burn-induced coagulopathy will be reviewed.
AB - Burn-induced coagulopathy is not well understood, and consensus on diagnosis, prevention, and treatments are lacking. In this review, literature on burn-induced (and associated) coagulopathy is presented along with the current understanding of the effects of burn injury on the interactions among coagulation, fibrinolysis, and inflammation in the acute resuscitative phase and reconstructive phase of care. The role of conventional tests of coagulopathy and functional assays like thromboelastography or thromboelastometry will also be discussed. Finally, reported methods for the prevention and treatment of complications related to burn-induced coagulopathy will be reviewed.
UR - http://www.scopus.com/inward/record.url?scp=85088177569&partnerID=8YFLogxK
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U2 - 10.1097/SHK.0000000000001484
DO - 10.1097/SHK.0000000000001484
M3 - Article
C2 - 31804296
AN - SCOPUS:85088177569
VL - 54
SP - 154
EP - 167
JO - Shock
JF - Shock
SN - 1073-2322
IS - 2
ER -