Building the bridges to bioinformatics in nutrition research

Danielle G. Lemay, Angela M. Zivkovic, J. Bruce German

Research output: Contribution to journalArticle

19 Scopus citations

Abstract

Like other life sciences, nutrition science can benefit enormously from the techniques of bioinformatics. In this article, the steps necessary to enable bioinformatic approaches in nutrition research are outlined, from the short-range goal of immediately making data available in ad hoc author-defined formats to the longer range goals of full standardization of nutrition experiments and migration of all experimental data into databases. Several examples of what will be possible for nutrition researchers in this new paradigm are described. Ultimately, nutrition data can be continually recycled to reinvestigate existing hypotheses and to generate new hypotheses that would not have been conceivable at the time of the original experiments. The standardization of experimental designs and the conversion of nutrition data into a machine-readable format will bring about a renaissance in nutrition research, accelerating the ability of investigators to discover the implications of nonessential nutrients and food components, and enable the study of complex metabolic interactions in human health and disease.

Original languageEnglish (US)
Pages (from-to)1261-1269
Number of pages9
JournalAmerican Journal of Clinical Nutrition
Volume86
Issue number5
StatePublished - Nov 1 2007

Keywords

  • Applied bioinformatics
  • Bioinformatics
  • Biomarker discovery
  • Biomarkers
  • Bioprofiles
  • Computational biology
  • Databases
  • Genomics
  • Informatics
  • Meta-analysis
  • Nutrigenomics
  • Nutrition
  • Nutrition standards
  • Ontologies
  • Standardization
  • Systems biology

ASJC Scopus subject areas

  • Medicine (miscellaneous)
  • Food Science

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    Lemay, D. G., Zivkovic, A. M., & German, J. B. (2007). Building the bridges to bioinformatics in nutrition research. American Journal of Clinical Nutrition, 86(5), 1261-1269.