Building biomarker libraries with novel chemical sensors: Correlating differential mobility spectrometer signal outputs with mass spectrometry data

Michael Schivo, Alexander A. Aksenov, Hamzeh Bardaweel, Weixiang Zhao, Nicholas Kenyon, Cristina E Davis

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Abstract

Gas chromatography/mass spectrometry (GC/MS) is a widely used analytic tool for qualitative and quantitative analysis of volatile and semi-volatile compounds. However, GC/MS use is limited by its large size, lack of portability, high cost and inherent complexity. Smaller instruments capable of high-throughput analysis of volatile compounds have the potential of combining MS-like sensitivity with portability. The micromachined differential mobility spectrometer (DMS) is a miniature sensor capable of registering volatile compounds in sub-parts-per-million (ppm) concentrations. It is small, portable, and can be coupled with multiple other compound separation methods. Here we describe paired volatile sample analyses using both GC/MS and GC/DMS which show that the DMS is capable of registering known compounds as verified by MS. Furthermore, we show that MS can be used to help build a library for our unique DMS sensor outputs and detect compounds in chemically complex backgrounds.

Original languageEnglish (US)
Title of host publicationIOP Conference Series: Materials Science and Engineering
Volume18
EditionSYMPOSIUM 15
DOIs
Publication statusPublished - 2011
Event3rd International Congress on Ceramics, ICC3 - Osaka, Japan
Duration: Nov 14 2010Nov 18 2010

Other

Other3rd International Congress on Ceramics, ICC3
CountryJapan
CityOsaka
Period11/14/1011/18/10

    Fingerprint

ASJC Scopus subject areas

  • Materials Science(all)
  • Engineering(all)

Cite this