Building better tumor models: Organoid systems to investigate angiogenesis

Venktesh S. Shirure, Mary Kathryn Sewell-Loftin, Sandra F. Lam, Tyson D. Todd, Priscilla Y. Hwang, Steven C. George

Research output: Chapter in Book/Report/Conference proceedingChapter

Abstract

Cancer remains a leading cause of death in the United States and other developed countries. In nearly all cases, the cause of death is related to complications associated with tumor metastasis to distant sites such as the brain, lung, liver, and bone. A central feature of tumor progression is the acquisition of a blood supply, which provides nutrients for the growing tumor as well as conduits for transport of cancer cells. Our understanding of how a tumor acquires and manipulates a blood supply has been gleaned largely from animal models, but more recent advances in tissue engineering and microfabrication have led to clever 3D in vitro models of tumors that include blood vessels. This chapter will first briefly review the process of blood vessel growth including our knowledge of blood vessels within the cancer microenvironment, and discuss the most recent advances to mimic blood vessel growth in the tumor microenvironment using 3D in vitro culture methods. Finally, we discuss several important factors that control blood vessel growth including hypoxia, cellular metabolism, and tissue mechanics, which provide rich opportunities for future investigation.

Original languageEnglish (US)
Title of host publicationCancer Drug Discovery and Development
PublisherHumana Press Inc.
Pages117-148
Number of pages32
Edition9783319605098
DOIs
StatePublished - 2018
Externally publishedYes

Publication series

NameCancer Drug Discovery and Development
Number9783319605098
Volume0
ISSN (Print)2196-9906
ISSN (Electronic)2196-9914

Keywords

  • 3D models
  • Cancer microenvironment
  • Hypoxia
  • Mechanics
  • Metabolism
  • Metastasis
  • Tissue engineering

ASJC Scopus subject areas

  • Cancer Research
  • Oncology
  • Drug Discovery

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