Buccal administration of human colostrum: Impact on the oral microbiota of premature infants

K. Sohn, K. M. Kalanetra, D. A. Mills, Mark Underwood

Research output: Contribution to journalArticle

26 Scopus citations

Abstract

Objective: To determine whether the administration of mother's colostrum into the buccal pouch in the first days of life alters the oral microbiota compared with control infants. Study Design: In this pilot study, 12 very low birth weight (VLBW) infants were randomly assigned to receive either colostrum from their mothers directly into the buccal pouch every 2 h for 46 h or standard care. We analyzed the oral microbiota at initiation and 48 and 96 h later using next-generation sequencing. Result: The oral microbiota changed markedly over the 96 h period in all babies. Patterns of colonization differed between groups with Planococcaceae, the dominant family at 48 and 96 h in the colostrum group, and Moraxellaceae and Staphylococcaceae, the dominant families at 48 and 96 h, respectively, in the control group. Conclusion: Buccal administration of mother's colostrum to VLBW infants influenced the colonization of the oral cavity with differences persisting 48 h after completion of the intervention.

Original languageEnglish (US)
Pages (from-to)106-111
Number of pages6
JournalJournal of Perinatology
Volume36
Issue number2
DOIs
StatePublished - Feb 1 2016

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ASJC Scopus subject areas

  • Obstetrics and Gynecology
  • Pediatrics, Perinatology, and Child Health

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