Objective: To determine whether the administration of mother's colostrum into the buccal pouch in the first days of life alters the oral microbiota compared with control infants. Study Design: In this pilot study, 12 very low birth weight (VLBW) infants were randomly assigned to receive either colostrum from their mothers directly into the buccal pouch every 2 h for 46 h or standard care. We analyzed the oral microbiota at initiation and 48 and 96 h later using next-generation sequencing. Result: The oral microbiota changed markedly over the 96 h period in all babies. Patterns of colonization differed between groups with Planococcaceae, the dominant family at 48 and 96 h in the colostrum group, and Moraxellaceae and Staphylococcaceae, the dominant families at 48 and 96 h, respectively, in the control group. Conclusion: Buccal administration of mother's colostrum to VLBW infants influenced the colonization of the oral cavity with differences persisting 48 h after completion of the intervention.
ASJC Scopus subject areas
- Obstetrics and Gynecology
- Pediatrics, Perinatology, and Child Health