Brush border antibody of Heymann nephritis of rats was detected in 36.0% of normal human sera by indirect immunofluorescence technique. Persons with blood group B were less likely to develop this antibody. Its existence in the serum may or may not be related to the genesis of idiopathic membranous glomerulonephropathy in humans. Many investigators are looking for BBAb in the sera of patients with renal disease; thus, it is important to know that BBAb can exist in the sera of normal human controls who do not have any clinical evidence of renal disease. Further studies on this subject will be needed to understand the significance of this observation. Possibilities to explain this observation are presented.
|Original language||English (US)|
|Number of pages||5|
|Journal||Proceedings of the Society for Experimental Biology and Medicine|
|State||Published - 1977|
ASJC Scopus subject areas
- Biochemistry, Genetics and Molecular Biology(all)