Brush border antibodies of Heymann nephritis of rats in normal human serum

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Abstract

Brush border antibody of Heymann nephritis of rats was detected in 36.0% of normal human sera by indirect immunofluorescence technique. Persons with blood group B were less likely to develop this antibody. Its existence in the serum may or may not be related to the genesis of idiopathic membranous glomerulonephropathy in humans. Many investigators are looking for BBAb in the sera of patients with renal disease; thus, it is important to know that BBAb can exist in the sera of normal human controls who do not have any clinical evidence of renal disease. Further studies on this subject will be needed to understand the significance of this observation. Possibilities to explain this observation are presented.

Original languageEnglish (US)
Pages (from-to)9-13
Number of pages5
JournalProceedings of the Society for Experimental Biology and Medicine
Volume154
Issue number1
StatePublished - 1977
Externally publishedYes

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Membranous Glomerulonephritis
Brushes
Microvilli
Rats
Antibodies
Blood Group Antigens
Serum
Kidney
Indirect Fluorescent Antibody Technique
Research Personnel

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)

Cite this

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abstract = "Brush border antibody of Heymann nephritis of rats was detected in 36.0{\%} of normal human sera by indirect immunofluorescence technique. Persons with blood group B were less likely to develop this antibody. Its existence in the serum may or may not be related to the genesis of idiopathic membranous glomerulonephropathy in humans. Many investigators are looking for BBAb in the sera of patients with renal disease; thus, it is important to know that BBAb can exist in the sera of normal human controls who do not have any clinical evidence of renal disease. Further studies on this subject will be needed to understand the significance of this observation. Possibilities to explain this observation are presented.",
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AB - Brush border antibody of Heymann nephritis of rats was detected in 36.0% of normal human sera by indirect immunofluorescence technique. Persons with blood group B were less likely to develop this antibody. Its existence in the serum may or may not be related to the genesis of idiopathic membranous glomerulonephropathy in humans. Many investigators are looking for BBAb in the sera of patients with renal disease; thus, it is important to know that BBAb can exist in the sera of normal human controls who do not have any clinical evidence of renal disease. Further studies on this subject will be needed to understand the significance of this observation. Possibilities to explain this observation are presented.

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