Brucella spp. virulence factors and immunity

Mariana X. Byndloss, Renee M Tsolis

Research output: Contribution to journalReview article

44 Scopus citations

Abstract

Brucellosis, caused by bacteria of the genus Brucella, is an important zoonotic infection that causes reproductive disease in domestic animals and chronic debilitating disease in humans. An intriguing aspect of Brucella infection is the ability of these bacteria to evade the host immune response, leading to pathogen persistence. Conversely, in the reproductive tract of infected animals, this stealthy pathogen is able to cause an acute severe inflammatory response. In this review, we discuss the different mechanisms used by Brucella to cause disease, with emphasis on its virulence factors and the dichotomy between chronic persistence and reproductive disease.

Original languageEnglish (US)
Pages (from-to)111-127
Number of pages17
JournalAnnual Review of Animal Biosciences
Volume4
DOIs
StatePublished - Feb 15 2016

Keywords

  • Brucellosis
  • Chronic disease
  • Immune response
  • Reproduction

ASJC Scopus subject areas

  • Animal Science and Zoology
  • veterinary(all)
  • Biotechnology
  • Genetics

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