Brucella spp. virulence factors and immunity

Mariana X. Byndloss, Renee M Tsolis

Research output: Contribution to journalReview article

37 Citations (Scopus)

Abstract

Brucellosis, caused by bacteria of the genus Brucella, is an important zoonotic infection that causes reproductive disease in domestic animals and chronic debilitating disease in humans. An intriguing aspect of Brucella infection is the ability of these bacteria to evade the host immune response, leading to pathogen persistence. Conversely, in the reproductive tract of infected animals, this stealthy pathogen is able to cause an acute severe inflammatory response. In this review, we discuss the different mechanisms used by Brucella to cause disease, with emphasis on its virulence factors and the dichotomy between chronic persistence and reproductive disease.

Original languageEnglish (US)
Pages (from-to)111-127
Number of pages17
JournalAnnual Review of Animal Biosciences
Volume4
DOIs
StatePublished - Feb 15 2016

Fingerprint

Brucella
Virulence Factors
Immunity
reproductive disorders
virulence
immunity
Bacteria
animal pathogens
Brucellosis
bacteria
Domestic Animals
Zoonoses
brucellosis
chronic diseases
domestic animals
infection
Chronic Disease
inflammation
immune response
pathogens

Keywords

  • Brucellosis
  • Chronic disease
  • Immune response
  • Reproduction

ASJC Scopus subject areas

  • Animal Science and Zoology
  • veterinary(all)
  • Biotechnology
  • Genetics

Cite this

Brucella spp. virulence factors and immunity. / Byndloss, Mariana X.; Tsolis, Renee M.

In: Annual Review of Animal Biosciences, Vol. 4, 15.02.2016, p. 111-127.

Research output: Contribution to journalReview article

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